Filagra DXT Plus

Last Updated on 10/09/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What Is Filagra DXT Plus?

Filagra DXT Plus is listed by multiple online pharmacies and supplier websites as a combination tablet containing two active substances: sildenafil citrate and duloxetine.

The manufacturer named across these listings is Fortune Healthcare Pvt. Ltd., an Indian pharmaceutical company.

It is important to recognise that Filagra DXT Plus is a trade name used in commercial distribution, not a verified medicine identity that has been independently assessed by a national medicines regulator in the way registered prescription medicines are. A trade name alone does not confirm that a product meets the quality, safety and efficacy standards required for formal registration.

Product specific evidence is needed before any intended use can be described reliably. Information about individual ingredients such as sildenafil and duloxetine is well established in prescribing literature, but that knowledge does not automatically extend to a fixed dose combination sold under a particular brand.

Each combination product requires its own evaluation through appropriate clinical and regulatory processes.

Filagra DXT Plus Ingredients and Strength

Sildenafil citrate

According to product listings, each Filagra DXT Plus tablet contains sildenafil citrate at a strength of 100mg.

Sildenafil citrate is the salt form of sildenafil and is the active ingredient in several prescription medicines approved for erectile dysfunction. The 100mg strength corresponds to the highest standard dose in authoritative prescribing information.

However, the strength stated in third party supplier listings should be confirmed against the manufacturer package insert or an official regulatory database before it is relied upon.

Duloxetine

Product listings describe the second ingredient as duloxetine at 60mg.

Duloxetine is classified as a serotonin and norepinephrine reuptake inhibitor with established indications including:

• Major depressive disorder
• Generalised anxiety disorder
• Certain pain conditions

The 60mg strength falls within the dosing range described in prescribing information for several of these indications. As with sildenafil, the stated strength requires verification through manufacturer documentation.

Product specifications

The table below summarises the details gathered from publicly available product listings. Items that could not be confirmed through manufacturer or regulatory documentation are marked as unconfirmed.

How Does Sildenafil Work In Filagra DXT Plus ?

Sildenafil is classified as a phosphodiesterase type 5 inhibitor, commonly referred to as a PDE5 inhibitor.

According to authoritative prescribing information, the physiological mechanism of an erection involves the release of nitric oxide in the corpus cavernosum during sexual stimulation. Nitric oxide then activates an enzyme called guanylate cyclase, which increases levels of cyclic guanosine monophosphate, or cGMP.

This increase produces smooth muscle relaxation in the corpus cavernosum and allows inflow of blood.

Sildenafil enhances the effect of nitric oxide by inhibiting PDE5, the enzyme responsible for the breakdown of cGMP. When sexual stimulation causes local release of nitric oxide, the inhibition of PDE5 by sildenafil leads to increased cGMP levels, resulting in smooth muscle relaxation and increase blood flow into the penis.

Prescribing information states clearly that sildenafil has no effect in the absence of sexual stimulation.

The mechanism of an ingredient does not establish the performance of a particular branded combination, and no specific onset time or duration should be assumed for Filagra DXT Plus without reliable product specific evidence.

What Is Duloxetine and How Does It Work?

Duloxetine is classified as a serotonin and norepinephrine reuptake inhibitor, or SNRI. It is not an SSRI, which is a separate class that acts selectively on serotonin reuptake alone.

According to authoritative prescribing information, duloxetine is indicated for the treatment of:

• Major depressive disorder
• Generalised anxiety disorder
• Diabetic peripheral neuropathic pain
• Fibromyalgia
• Chronic musculoskeletal pain

Its mechanism involves increasing the levels of serotonin and noradrenaline in the central nervous system by inhibiting their reuptake at neuronal synapses. Duloxetine has no significant affinity for most other receptor types.

Importantly, duloxetine is not an established or approved treatment for premature ejaculation in any major regulatory system. While some research has explored duloxetine for this purpose, prescribing information does not list premature ejaculation as an approved indication.

Additionally, duloxetine is associated with sexual adverse effects, including:

• Ejaculatory delay or failure
• Decreased libido
• Erectile dysfunction

These effects represent pharmacological actions of the medicine, not a clinically established treatment indication. The presence of duloxetine in a combination product name does not by itself confirm that the product is an approved treatment for any particular condition.

What Does the Evidence Say About the Combination?

Sildenafil as an individual medicine has been extensively studied and is approved for erectile dysfunction in many countries. Its efficacy and safety profile is well documented in prescribing information based on multiple clinical trials.

Duloxetine as an individual medicine has also been studied and approved for its established indications, with clinical evidence supporting its use in depression, anxiety and certain pain conditions.

However, whether this specific fixed dose combination of sildenafil and duloxetine has been evaluated in reliable clinical studies is a separate question. A review of the published literature did not identify robust clinical trials that specifically test the sildenafil plus duloxetine combination as a single tablet.

Some studies have examined sildenafil combined with dapoxetine, which is a different medicine. Dapoxetine is a short acting SSRI specifically approved for premature ejaculation in many countries, whereas duloxetine is an SNRI approved for different indications. Research on sildenafil plus dapoxetine cannot be substituted for evidence on sildenafil plus duloxetine because these are pharmacologically distinct medicines with different properties, dosing and safety profiles.

What remains unknown is the product specific effectiveness, tolerability and long term outcomes of the Filagra DXT Plus combination. For further information about dapoxetine’s role in premature ejaculation, read our guide to dapoxetine for premature ejaculation.

Filagra DXT Plus Safety Information and Precautions

Medical history and suitability

Before considering any medicine containing sildenafil and duloxetine, a qualified healthcare professional needs to assess your full medical history.

Cardiovascular conditions such as heart disease, angina, previous heart attack or irregular heartbeat are relevant because sildenafil affects blood pressure and cardiovascular physiology. Blood pressure levels, both high and low, require evaluation.

Existing diagnoses that should be disclosed include:

• Liver or kidney problems
• Bleeding tendencies
• Mood disorders
• Any history of serotonin related conditions

A prescriber also needs to know about all other medicines you currently take, including over the counter products and supplements, because both sildenafil and duloxetine have clinically significant interaction profiles.

Important contraindications

According to authoritative prescribing information, sildenafil is contraindicated in patients using:

• Organic nitrates in any form, either regularly or intermittently, due to the risk of serious blood pressure reduction
• Riociguat
• Any known hypersensitivity to the medicine

Duloxetine is contraindicated with monoamine oxidase inhibitors used for psychiatric disorders and within specific washout periods before or after their use.

These contraindications are established for the individual ingredients and are drawn from their prescribing information. A product specific contraindication list for Filagra DXT Plus cannot be constructed without manufacturer or regulatory documentation.

When to seek medical advice

New symptoms, suspected drug interactions or any uncertainty about the identity or contents of the product should prompt consultation with a healthcare professional.

If you experience any of the following, seek urgent medical attention:

• Chest pain
• Sudden vision changes
• Hearing loss
• A prolonged erection
• Signs of an allergic reaction

This page does not provide a self prescribing protocol or dosage schedule. Decisions about suitability, dosing and monitoring belong with a qualified prescriber who has access to your complete health record.

For general information about sildenafil administration, read when and how sildenafil should be taken. The guidance for sildenafil alone should not be assumed to establish dosing instructions for this combination product.

Filagra DXT Plus Side Effects

The recognised adverse effects of sildenafil, including their severity and frequency, are discussed in our guide to sildenafil side effects. According to prescribing information, the most commonly reported adverse reactions with sildenafil include:

The adverse effect rates established for sildenafil and duloxetine individually should not be assumed to represent the combined product. No combined product statistics are available in the absence of specific clinical studies for Filagra DXT Plus.

Drug Interactions and Other Considerations

Sildenafil has a well documented interaction with organic nitrates. Prescribing information states that sildenafil potentiates the blood pressure lowering effect of nitrates, making concurrent use contraindicated.

Other medicines that lower blood pressure, including alpha blockers and certain antihypertensives, may also interact with sildenafil and require medical review.

Duloxetine interacts with other serotonergic medicines, including:

• Selective serotonin reuptake inhibitors
• Serotonin and norepinephrine reuptake inhibitors
• Triptans
• Tramadol
• Certain other agents

The combination can increase the risk of serotonin syndrome, a potentially serious condition. Duloxetine also interacts with monoamine oxidase inhibitors, and concurrent use is contraindicated. Other clinically significant interactions involve medicines that affect duloxetine metabolism.

Alcohol consumption is relevant to both ingredients. Prescribing information advises caution with alcohol for both sildenafil and duloxetine, and combining the two may increase the risk of dizziness or other effects.

A full medication reconciliation by a prescriber or pharmacist is essential before starting any product containing these ingredients. Separating doses by a particular number of hours does not automatically prevent interactions, as some interactions depend on ongoing enzyme effects or cumulative serotonergic activity rather than timing alone.

Filagra DXT vs Filagra DXT Plus

Products with similar names should never be assumed to contain identical ingredients or strengths.

Based on publicly available listings:

• Filagra DXT is described as containing sildenafil citrate 100mg and duloxetine 30mg
• Filagra DXT Plus is described as containing sildenafil citrate 100mg and duloxetine 60mg

The apparent difference lies in the duloxetine strength. However, any comparison should be based on verified manufacturer documentation rather than third party listings alone.

A comparison table should be published only when both products can be confirmed independently through official sources. If the formulations cannot be verified, speculating about differences risks creating inaccurate information.

Filagra DXT Plus Storage

Keep Filagra DXT Plus out of reach of children and pets at all times. Do not use the tablets after the expiry date printed on the packaging. If you have any unused or expired medicine, ask your pharmacist about the safest way to dispose of it. Never flush tablets down the toilet or throw them in household bins without proper guidance.