Alpostin 500 Mcg Injection (Alprostadil)

Last Updated on 01/29/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What Is Alpostin 500 Mcg Injection?

Alpostin 500 mcg Injection contains Alprostadil (Prostaglandin E1) and is a prescription-only hospital medicine in Australia.

Alpostin 500 mcg injection is an injection that is given to a male person with the ED or erectile dysfunction disorder. Having this disorder means that the person is not able to get a hard and strong erection.

Even if you do not get a hard erection or wonder if you are not able to maintain it, there is no need to worry now. The Alpostin 500 mcg injection is there to give you a strong erection within just a few minutes.

This is a new form of ED remedy where the doctors give you an injection into your muscles in the body that gets rid of any ED signs.

What Is It Used For In Australia?

In Australian clinical practice, alprostadil injections are used mainly to:

• Maintain patency of the ductus arteriosus in newborns with certain congenital heart defects

• Support blood circulation until corrective cardiac surgery can be performed

This use is specialist-directed and typically managed by neonatologists or paediatric cardiologists.

Key Points

• Active ingredient: Alprostadil (Prostaglandin E1)
• Strength: 500 micrograms (mcg)
• Composition: Alprostadil is a form of vasodilator medication that helps dilate the arteries.
• Manufacturer: Samarth Lifesciences Pvt. Ltd. has the exclusive rights to manufacture this medicine in India.
• Drug class: Vasodilator / Prostaglandin
• Primary use: Keeps the ductus arteriosus open in newborns with congenital heart defects
• Route: Intravenous (IV) infusion
• Setting: Hospital use only
• Onset: Rapid action after infusion begins
• Monitoring: Continuous monitoring of breathing, heart rate, and blood pressure
• Common side effects: Apnoea, low blood pressure, fever, flushing
• Prescription: Specialist-prescribed (neonatology/paediatrics)
• Not for self-use: Must be administered by trained healthcare professionals

Method Of Daily Use For Alpostin 500 Mcg Injection

• Depending on your condition, you may not even have to use the Alpostin 500 mcg injection daily.
• A single use of the injection can last a few hours, given the amount of dose you are using.
• Only in case of a more severe ED, an issue not curable with other remedies used before, will the doctors tell you to take the Alpostin 500 mcg injection daily.
• However, since it is a kind of injection, it is always a good idea to take the help of the doctors to administer the vaccine in your body for proper use.

How Does Alpostin 500 Mcg Injection Work?

• Relaxes smooth muscle in blood vessels
• Causes vasodilation, improving blood flow
• Keeps the ductus arteriosus open in affected newborns
• The Alpostin 500 mcg injection works based on dilation.
• First, under the action of Alprostadil, the PDE-5 hormones are inhibited.
• This increases the affinity for the cGMP enzyme.
• It is here that nitric oxide gets active and starts producing its dilation effects.
• This is the effect where the blood vessels dilate or widen, giving more blood flow to the penis tissues.

✓ How It Is Given

• Administered as an intravenous (IV) infusion

• Given only in hospital settings

• Requires continuous monitoring (heart rate, breathing, blood pressure)

Alpostin 500 Mcg Injection- How Long Does It Last?

• Your erection after using the injection will last close to one to 2 hours easily.
• Typically, you get a hard erection within 30 minutes of using the vaccine.

Is Alpostin 500 mcg Injection an effective injection?

Yes, the Alpostin injection is more effective since the drug inside is injected directly into the bloodstream, which has a more direct action.

Dosage Of Alpostin 500 Mcg Injection

✓ For Mild ED Problems

• Use the Alpostin 500 mcg injection up to 3 to 4 times per week, keeping at least 24 hours between doses.
• The doctors can also give you a smaller strength, like the 250-mcg dose.

✓ For Severe ED

• In case of severe ED issues, the doctors can tell you to administer the injection daily.

✓ What Happens If I Miss Taking A Dose?

In case you miss taking your dose for even a single day, you may not get a hard erection during sex. Also, note that it reduces the action of the medicine in your body.

✓ What Happens If I Overdose On This Medicine?

The moreyour overdose, the higher the risk of severe side effects. Remember that the instructions for using the medicine are to always use the right dose. Excess Alprostadil can cause harmful effects in your body in the end.

Alpostin 500 mcg Injection – Age-wise Dosage

✓ Newborns / Neonates (Primary Use)

Used to maintain ductus arteriosus patency in congenital heart defects.

• Starting dose:
  0.05–0.1 micrograms/kg/min (IV infusion)

• Maintenance dose:
  Reduced to 0.01–0.05 micrograms/kg/min once adequate response is achieved

• Administration:
  Continuous intravenous infusion

• Monitoring required:
  Breathing (risk of apnoea), heart rate, blood pressure, oxygen levels

✓ Infants & Children

• Use is rare and highly specialised

• Dose is individualised by paediatric cardiology specialists

• Always given in a hospital setting

✓ Adults

• Alpostin 500 mcg injection is NOT typically used in adults

• Alprostadil for adults (e.g., erectile dysfunction) uses different formulations and doses

Benefits Of Taking Alpostin 500 Mcg Injection

• By using the Alpostin 500 mcg injection, you now have a solution to get hard any time and have sex without any issues of losing or not getting hard.
• It typically helps you get erections faster than ED medicines.
• It has a more direct action, which ensures an erection even for severe ED problems.

Precautions And Warnings

✓ With Alcohol

Alcohol and narcotic drugs are to be avoided. These can cause all forms of minor or sometimes even severe side effects.

✓ Driving

People driving, especially those who have taken the Alpostin 500 mcg injection dose and start to feel dizziness or nausea, must avoid driving.

Drug Interaction Classification

✓ With Other Medicines

• Nitrate injections
• PDE-5 hormone blockers
• Medicines of the alpha and beta blocker categories

✓ With Other Health Issues

The doctors strictly do not recommend this medicine to patients with high BP, a major heart disorder, or right after heart surgery.

✓ With Food

Studies even show that the use of Alpostin 500 mcg injection is not suitable for some types of food items. Earlier scientists have found some types of food that may cause interactions with the medicine and cause side effects. All these food items are high sources of nitrates.

What Are The Side Effects Of Alpostin 500 Mcg Injection?

✓ Common Side Effects

• Stomach pain
• Weaknesses
• Bloating
• Diarrhea
• Allergic reactions at the site of injection
• Skin rashes
• Nausea
• Headache
• Dizziness

These mild issues should only last for a few days and go away.

✓ Severe Side Effects

• Chest pain
• Vision blur
• Rise of BP
• Priapism

✓ Precautions And Warnings

• The standard dosage recommendation from the doctors is to use a single injection for daily use.
• The doctors will tell you how long you need to use this medicine.
• Keep using the medicine until the end of the tenure and do not stop taking it.
• Remember that each dose is able to give a temporary effect for a few hours.

When To Seek Medical Help?

• Always take medical help from the doctors during consultation ofonour dose.
• Do not forget to have the doctors administer the right dose inside your body.
• Take medical help in case the current dose is not working properly for a few hours, and you want to increase the strength of the injection.

Safety Advice Of Alpostin 500 Mcg Injection

✓ In Case Of Allergic Side Effects

Some patients may be completely allergic to Alprostadil. In such a case, you can get side effects like-

• Rashes
• Itching
• Swelling

Stop using the medicines due to such side effects.

✓ For Males With ED

Taking Alprostadil as a chief generic component is only for the sexual condition of ED in males. Each injection lasts for some timeduringn which you can get free of any ED symptoms.

✓ Key Safety Notes

• Not for home use

• Dose depends on weight, condition, and response

• Risk of apnoea, especially in premature infants

• Requires immediate access to respiratory support

Storage Instructions

Store the Alpostin 500 mcg injection in an area of low heat and humidity. It is better not to keep the medicine in the fridge or directly in the sunlight.

For storage, always look for a safe and locked place in your house such that the sachet of medicines is protected from your child’s reach.

Is Alpostin 500 Mcg Injection Legal In Sydney?

Yes, it is legal to buy Alpostin 500 mcg injection in Sydney using a prescription after the TGA mandated its use for use in males with ED, but with a prescription only.

Where To Buy Alpostin 500 Mcg Injection In Australia?

To buy Alpostin 500 mcg injection in Australia, check out authorised websites that are approved by the TGA in Australia, like AustraliaRXMeds.

In simple terms

In Australia, Alpostin 500 mcg Injection is a hospital-only medicine used to support critically ill newborns with heart defects by improving blood flow until surgery is possible.

FAQs