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Zydalis 20 Mg

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Zydalis 20 mg contains tadalafil, a medicine used to treat erectile dysfunction (ED) in men. It helps improve blood flow to the penis during sexual stimulation, supporting an erection when needed.

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40 Tablet/s AUD $109.99 (2.74 / Unit) Add To Cart
60 Tablet/s AUD $160.39 (2.67 / Unit) Add To Cart
120 Tablet/s AUD $302.45 (2.52 / Unit) Add To Cart
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Active-Ingredient Tadalafil
Manufacturers
Packaging 4 Tablets In 1 Strip
Strength 20mg
Delivery-Time 6 To 15 days
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Active-Ingredient Tadalafil
Manufacturers
Packaging 4 Tablets In 1 Strip
Strength 20mg
Delivery-Time 6 To 15 days

Zydalis 20 mg contains tadalafil, a medicine used to treat erectile dysfunction (ED) in men. It helps improve blood flow to the penis during sexual stimulation, supporting an erection when needed.

Last Updated on ✔ Medically Reviewed by Dr. Arjun Srivastav

What Is Zydalis 20 mg?

Zydalis 20 mg is a tadalafil-containing medicine that belongs to a group of medicines called phosphodiesterase type 5 (PDE5) inhibitors. It is used to manage erectile dysfunction, a condition in which a man has difficulty getting or maintaining an erection firm enough for sexual activity.

Tadalafil works by relaxing certain blood vessels and improving blood flow to the penis in response to sexual stimulation. It does not create sexual desire or cause an automatic erection.

Tadalafil is also prescribed in different treatment regimens for conditions such as benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension (PAH). However, the dose and treatment instructions differ between conditions, so these uses should not automatically be attributed to Zydalis 20 mg.

What Is Zydalis 20 mg Used For?

Zydalis 20 mg is used to treat erectile dysfunction in adult men. ED can occur for several reasons, including circulation problems, certain medical conditions, medication effects, stress or psychological factors.

By supporting the blood-flow response involved in an erection, tadalafil can help men who have difficulty achieving or maintaining one during sexual activity.

The medicine does not treat every underlying cause of ED. A healthcare professional can help determine whether tadalafil is suitable and whether another condition may be contributing to the problem.

How Does Zydalis 20 mg Work?

An erection involves a coordinated response between the nervous system, blood vessels and penile tissue. During sexual stimulation, the body releases nitric oxide, which helps relax the smooth muscles in the penis and allows more blood to enter.

Tadalafil blocks the PDE5 enzyme, which normally breaks down a substance called cyclic guanosine monophosphate (cGMP). By slowing this breakdown, tadalafil helps maintain the blood-vessel relaxation needed for an erection.

Sexual stimulation is still necessary for the medicine to work. Tadalafil does not increase sexual desire, and taking a tablet does not guarantee an erection.

How Long Does Zydalis 20 mg Last?

Tadalafil is known for its relatively long period of activity. For many men, its effect on the ability to respond to sexual stimulation can last up to 36 hours after a dose.

This does not mean an erection lasts for 36 hours. Rather, the medicine may help with the erectile response during that period when sexual stimulation occurs. Individual results can differ, and the medicine does not guarantee a particular outcome.

The time it takes to begin working also varies. Follow the timing advised by your prescriber and do not take extra tablets if the response is slower than expected.

How to Take Zydalis 20 mg

Follow the instructions provided by the prescribing healthcare professional and the product leaflet. The correct administration method depends on the exact formulation supplied.

  • Swallow a conventional tablet with water if that is the formulation specified on its packaging.
  • Take it at the prescribed time and do not use more than the recommended amount.
  • Food does not usually have a significant effect on the absorption of conventional tadalafil tablets.
  • Do not combine it with another tadalafil-containing product or another ED pill unless your prescriber has specifically advised you to do so.
  • Do not change the dose or frequency based on your response without medical advice.

If the product is labelled as a mouth-dissolving or orally disintegrating tablet, follow its specific instructions rather than assuming it should be taken like a conventional tablet.

Zydalis 20 mg Dosage

The appropriate dose depends on the condition being treated, other medicines being taken, kidney or liver function and the individual’s response to treatment.

For erectile dysfunction, tadalafil may be prescribed for use when needed or as a lower-dose daily regimen. These schedules are not interchangeable, and a 20 mg tablet should not be treated as a routine daily dose unless a qualified prescriber has specifically instructed otherwise.

Do not take an additional tablet because the first dose seems ineffective. If the medicine does not help, discuss the result with your healthcare professional rather than increasing the amount yourself.

Available Strengths and Pack Information

The product discussed on this page is Zydalis 20 mg. Other strengths or formulations may be sold under similar brand names, but their availability and instructions should be checked against reliable product information.

AUD $2.06 / Tablet

Do not assume that Zydalis MD and a conventional Zydalis tablet are identical. Confirm the active ingredient, dosage form, strength and manufacturer details on the packaging before using the product.

Missed Dose

If tadalafil has been prescribed for use when needed for erectile dysfunction, there is generally no scheduled dose to make up. Take it only according to the prescribed instructions.

If you have a regular dosing schedule for another condition, follow the instructions supplied for that regimen. Do not double the next dose to compensate for a missed one.

Overdose

Taking more tablet than prescribed may increase the risk of tadalafil side effects, including headache, dizziness, low blood pressure and prolonged erection.

Seek urgent medical advice if you have taken too much. An erection lasting four hours or longer requires emergency medical care because delayed treatment can cause lasting damage.

Zydalis 20 mg Side Effects

Like other erectile dysfunction medicines, tadalafil can cause unwanted effects. Some are mild and temporary, while others require prompt medical attention.

😊 Common Side Effects

🚨 Serious Side Effects

😊 Common Side Effects

Headache or dizziness
Facial flushing
Indigestion or an upset stomach
Nasal congestion
Back pain and muscle aches

🚨 Serious Side Effects

An erection lasting four hours or longer
Sudden loss or change in vision
Sudden hearing loss
Chest pain
A severe allergic reaction
Headache or dizziness
An erection lasting four hours or longer
Facial flushing
Sudden loss or change in vision
Indigestion or an upset stomach
Sudden hearing loss
Nasal congestion
Chest pain
Back pain and muscle aches
A severe allergic reaction

Do not take another dose until a healthcare professional has assessed a suspected serious reaction.

Drug Interactions

Tadalafil can interact with medicines that affect blood pressure, circulation or the way the body processes the drug. Tell your prescriber about all prescription medicines, non-prescription products, vitamins, and supplements you use.

Medicine or substance Why it matters
Nitrates, such as nitroglycerin The combination can cause a dangerous fall in blood pressure and must be avoided.
Riociguat Combining it with tadalafil can cause a significant drop in blood pressure.
Alpha-blockers Some combinations may cause dizziness or low blood pressure, particularly when standing up.
Other blood-pressure medicines The combined effects may lower blood pressure further in some people.
Other ED medicines Combining treatments can increase side effects and should only occur under specialist direction.
Strong CYP3A4 inhibitors, such as certain antifungal or antibiotic medicines These can affect tadalafil breakdown and may increase exposure to the medicine.

Do not start, stop or change another medicine to accommodate tadalafil without discussing it with your prescriber.

Safety Advice for Zydalis 20 mg

Consult your healthcare professional before taking the medicine if you have existing medical conditions or use other medicines.

Heart Conditions

People with heart disease or recent cardiovascular events should seek medical advice before using it, and it must not be combined with nitrate medicines.

Liver and Kidney Health

Liver or kidney conditions may affect how it is processed, so medical assessment may be needed before treatment.

Women & Children

It is intended for ED in men and is not indicated for women or children for this purpose; it is used for other conditions and requires specific medical advice.

Alcohol

Excessive alcohol consumption may increase dizziness and low blood pressure when combined with the drug.

Driving & Operating Machinery

Avoid driving or operating machinery if this medication causes dizziness or changes in vision.

How to Store Zydalis 20 mg

Store the medicine according to the instructions on its packaging. General precautions include:

  • Keep it in its original packaging until needed.
  • Store it in a dry place away from excessive heat and moisture.
  • Avoid leaving it in direct sunlight or in a hot vehicle.
  • Keep it out of the reach and sight of children.
  • Check the expiry date before use.
  • Ask a pharmacist how to dispose of unused or expired tablets safely.

If the packaging gives different storage instructions, follow those instructions.

20 mg of Zydalis contains tadalafil, which helps manage erectile dysfunction by supporting the blood-flow response involved in an erection. The correct dose, product formulation and safety precautions matter when deciding whether it is suitable. AustraliaRXMeds provides product information to help readers understand the medicine, but a qualified healthcare professional should guide treatment decisions.

FAQs

1. How long does it take for Zydalis 20 mg tablets to work?

The medicine contains tadalafil. For erectile dysfunction, tadalafil is generally taken at least 30–60 minutes before sexual activity, although the time it takes to work can vary. Sexual stimulation is still needed for an erection.

2. What are the side effects of taking Zydalis 20 tablets?

Possible side effects of tadalafil include headache, facial flushing, indigestion, nasal congestion, back pain, and muscle aches. Seek urgent medical attention for chest pain, sudden vision or hearing changes, or an erection lasting four hours or longer.

3. How long do the effects of Zydalis 20mg last?

The drug may help with erectile function for up to 36 hours after a dose. This does not mean an erection lasts that long; sexual stimulation is needed, and individual responses vary.

4. Can Zydalis 20mg be taken with food?

These tablets can generally be taken with or without food. Follow the instructions supplied with your specific product, as directions may differ depending on its formulation.

5. Can Zydalis 20 be taken every day?

A 20 mg tadalafil dose is generally used when needed for erectile dysfunction rather than as a routine daily dose. Daily tadalafil treatment uses a different dosing regimen, so follow your prescriber's instructions and do not take extra doses.

6. Which medicines should not be taken with Zydalis 20mg?

It must not be taken with nitrate medicines used for chest pain or with riociguat because the combination can cause a dangerous drop in blood pressure. Some other medicines can also interact with tadalafil, so tell your healthcare professional about all medicines and supplements you use.

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About the Doctor

Dr. Arjun Srivastav

Medical Reviewer (Pharm D)

✔ Medically Reviewed • Updated: 10/10/2026

Education: Graduate Diploma in Clinical Practice - University of Sydney,

Clinical Pharmacist (Pharm D) Doctor of Medicine (MD) – University of Melbourne Biomedical Engineering – Monash University Graduate Diploma in Clinical Practice - University of Sydney, Arjun Srivastav is a dedicated Clinical Pharmacologist and the E-commerce Operations Manager at AustraliaRxMeds. With a Doctor of Pharmacy (Pharm D) and over 10 years of clinical experience at prestigious institutions like Wockhardt and Apollo Hospitals, Arjun specializes in drug safety, digital healthcare accessibility,...

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