Sildenafil Fluoxetine Tablet (100 mg/60 mg)

What Is Sildenafil Fluoxetine Tablet?

Sildenafil Fluoxetine Tablet is a combination drug with the PDE5 inhibitor, Sildenafil and the SSR inhibitor, Fluoxetine Hydrochloride. This is a drug whose two individual ingredients are approved by the TGA, and it can work for treating erectile dysfunction (ED) and Premature ejaculation (PE) at the same time.

• Manufacturer:

While many TGA-approved companies manufacture Sildenafil and Fluoxetine Hydrochloride individually, Fortune Healthcare Pvt. Ltd the combination drug.

• Composition And Appearance:

In the drug, 100 mg of sildenafil is present, and Fluoxetine Hydrochloride can be found in three combinations, 20mg, 40 mg and 60 mg. Depending on the combination, the API weight of the drug can vary between 120mg to 160mg.

• Onset Of Action:

1. Absorption rate: 30 to 60 minutes.
2. Time to reach the peak: Up to 2 hours.
3. Half Life: 5 to 4 hours.
4. A heavy meal can delay absorption by 30 to 60 minutes.

How Does Sildenafil Fluoxetine Tablet Work?

The two ingredients in the tablet work in two different ways but they work simultaneously to give the results:

Sildenafil’s mechanism:

• Influence Nitric Oxide: Nitric Oxide release is one of the prime activities of Sildenafil Fluoxetine, which it does by inhibiting PDE5. This relaxes the blood vessels and extra blood is induced into the penile veins.
• Influence cGMP: As PDE5 is inhibited, cGMP level increases and that makes the difference in blood flow to the penis, giving it a hard erection.

Fluoxetine Hydrochloride mechanism:

• Serotonin Increase: Serotonin receptors increase the chance of Premature ejaculation. Fluoxetine inhibits the reuptake of serotonin receptors to increase the timing of ejaculation.

Dosage Of Sildenafil Fluoxetine Tablet:

• Daily Dose: Not more than 1 tablet within 24 hours.
• Dosage timing: 1 to 3 hours before sexual intercourse.
• Dosage Warning: Prefer to have the tablet on an empty stomach. If facing nausea, have a light meal. Heavy meals delay absorption.
• Missed Dose: Take the missed dose as soon as you remember it but keep 24 hours difference from the last dose.
• Overdose: Overdose can be very much risky as it can cause back pain, dizziness, chest pain, or lower blood pressure.

Benefits Of Sildenafil Fluoxetine Tablet:

• Raise the standard of life: Get relief from sexual disorders like ED and PE to raise your standard of life.
• Boost up confidence: Give back confidence to males by boosting up their sexual ability in bed.
• Blood pressure reducer: Sildenafil also helps in reducing blood pressure.
• Cognitive Aid: Stress and anxiety related to incapability in bed and relationship takebacks are reduced.

Drug Interactions:

• MAO inhibitors: Inhibitors of MAO can react with Fluoxetine and cause toxic reactions.
• Nitrates: Usually used for chest pain and angina, when combined with Sildenafil Fluoxetine, can cause a serious lowering of Blood Pressure.
• CYP3A4 and CYP2D6: When these drugs come into contact with the combination, there can be a rise in Sildenafil levels, which can cause several side effects.
• Anticoagulant: Blood thinners and alpha-blockers can reduce blood pressure to a serious condition.

Side Effects:

Common Side Effects:

• Headache and dizziness: Stay hydrated to get the needful relief. Do not take blood pressure-reducing drugs.
• Nausea: Try to take the tablet with a light meal to avoid such conditions.
• Stomach upset: Avoid heavy meals to avoid such conditions.
• Blood pressure fall: A mild fall in blood pressure is common. Do not take alcohol with the drug, as that will create more uneasiness.

Serious Side Effects:

• Liver Impairment: If taking liver medicines, taking the combination drug can cause big impact on your liver.
• Cardiac Issues: Patients can face cardiac issues like shortness of breath or chest pain. Meet a doctor immediately.
• Priapism: Long extending and painful erection, if resulted, see a doctor immediately.
• Blood pressure fall: Drastic Blood pressure fall can be a serious symptom. See a doctor for extreme dizziness and avoid alcohol.

Precautions and Warnings:

• Nitrates: Never take nitrates that you use for angina tablets with any composition having Sildenafil. A serious blood pressure drop can be the result of the combination.
• Blood pressure Fluctuation: The combination drug can actually fluctuate your BP. Sildenafil, on one side, lowers BP, whereas the effect of fluoxetine hydrochloride can cause fluctuation in the BP. If you face strain in your heart for the same, reach a doctor fast.
• Liver issues: While Sildenafil inhibits the PDE5 enzyme, Fluoxetine inhibits the enzyme called CYP2D6. The combined force can cause issues for the liver, as your liver secretes most of the enzymes. If you have some existing liver issues, consider talking to your doctor before taking the drug.
• Mood Swings: Mood swings can happen for this combination drug and sometimes, it can cause extreme agitation or hallucination in you. If you face such things quite frequently, talk to your doctor for a way out.
• Gastrointestinal Bleeding: In some rare cases, the combination drug can cause gastrointestinal effects like bleeding or bruising. Anti-inflammatory NSAIDs can elevate the condition. So be careful with those.
• Hearing Loss: A PDE5 inhibitor can cause hearing disability temporarily. Most probably, this remains an effect of the lowered blood pressure. Sometimes, patients can face temporary loss of vision too. Always keep your doctor informed about all these.
• Priapism: PDE5 inhibitors result in a hard erection when sexually stimulated. At times, this erection becomes painful and it will not normalize even after 4 hours. If you face such issues, immediately see a doctor.

When Not To Use:

The conditions when you must not use Sildenafil Fluoxetine are:

• Allergic: When you are allergic to any one of the components, Sildenafil or Fluoxetine Hydrochloride.
• Nitrates: Never take any PDE5 inhibitor when you take Nitrates or poppers. They are angina tablets and they when combined to PDE5 inhibitors, can cause a severe drop in blood pressure.
• GS Stimulators: Combining Sildenafil Fluoxetine with GS Stimulators can cause Symptomatic Hypotension.
• Severe Heart issue: If you have a serious heart condition or have a history of angioplasty, avoid the drug.

Storage:

• Store: Store the drug at room temperature, away from moisture, extreme heat and extreme cold.
• Security: Keep the drug away from children’s and pets’ reach.

Where To Buy Sildenafil Fluoxetine Tablet In Australia?

Buy Sildenafil Fluoxetine from an authentic online store like Australiarxmeds. The combination drug is not approved by the TGA. Therefore, you will not get them from the offline stores. However, for avoiding counterfeits, choosing a TGA-approved authentic Online Pharmacy is essential.