Pradaxa 110 Mg

What is Pradaxa 110 Mg?

Pradaxa 110 mg is a blood thinner medicine that doctors prescribe to help prevent blood clots. The main ingredient in Pradaxa 110 mg is dabigatran Etexilate. Pradaxa 110 mg is part of a group of medicines called oral anticoagulants. Pradaxa 110 mg helps by blocking thrombin so that the blood does not clot easily. The doctors generally recommend this medicine for-

• Preventing stroke
• Patients suffering from deep vein thrombosis blood clot issues in the legs.
• Pulmonary embolism blood clot issues in the lungs
• After a knee or hip replacement surgery to avoid having blood clots in these regions.

Manufacturer:

Boehringer Ingelheim India Pvt.Ltd is the actual brand manufacturer of the Pradaxa and all its dose variants.

Composition and appearance:

• Active generic element: Inside each medicine is 110 mg of dabigatran Etexilate.
• Inactive ingredients: There are some other inactive substances, which are used to make the core and shell of the medicine and to control the release during its breakdown in the stomach. This are-
  • Capsule core pellets which contain tartaric acid, Hypromellose
  • Capsule shell which contains gelatin, titanium dioxide
• Appearance: Each pill is a hard gelatin capsule, oval in shape and having two halves each of distinct colour pale blue and creamy white.

Onset of action:

• Initial action: it begins to inhibit thrombin right when it begins to get absorbed in your stomach.
• Peak effects: The maximum anticoagulant ability of the medicine begins to peak within 30 minutes to an hour of having this medicine.
• Half-life: The drug has a half-life of 12 to 17 hours until it is cleared by the kidneys.

How Does Pradaxa 110 Mg Work?

• Direct Binding: The medicine called dabigatran goes into your blood and sticks to the thrombin enzymes that are floating around in your blood. This is what dabigatran does when it gets into your bloodstream.
• The Lockout: When dabigatran binds to thrombin, Pradaxa stops thrombin from working. It does this by blocking the part of thrombin where it normally interacts with fibrinogen. Therefore, thrombin cannot do its job because Pradaxa is, in the way.
• No Fibrin Net: This happens because thrombin is deactivated. When thrombin is deactivated, your body cannot make those fibrin strands. Without the fibrin net, blood platelets and the blood cells cannot stick together well to form a blood clot.

Dosage of Pradaxa 110 Mg:

Standard Dose:

• For stroke prevention and atrial fibrillation: The standard dosage of Pradaxa 110 mg is two pills taken daily. The doctors will advise you to take a single pill every 12 hours.
• Maintenance dose: This dosage is also recommended as a maintenance dose for treatment of deep vein thrombosis and pulmonary embolism.
• Post hip and knee replacement surgery: After surgery, the doctors start a dose within 4 hours as a single dose of 100 mg. From next day onwards, you have to take two pills of 110 mg each taken every 12 hours for up to 12 days in case of knee surgery and 35 days of a hip surgery.

Dosage adjustments:

• Kidney dysfunction: if you have kidney impairment, or kidney infection the doctors will recommend the 110 mg or smaller dose variants to avoid toxicity of the drug in your body.
• Age: To reduce the complexity of the medicine due to higher age, doctors mostly recommend the 110 mg dose only to patients above the age of 75 years.
• Administering your dose: You need to take your dose with water and swallow the pill. Maintain a gap of 12 hours at least in between successive doses.

Benefits of Pradaxa 110 Mg:

• Pradaxa helps prevent strokes well: For people, with heart rhythms that are not caused by a heart valve problem it greatly lowers the chance of a blood clot moving from the heart to the brain and causing a stroke.
• Clot Treatment and Prevention: It helps stop blood clots in your legs or lungs from getting bigger. This allows your body to dissolve them naturally. It also lowers the risk of clots forming.
• Targeted Protection Post-Surgery: You are at a risk of problems during this time so Targeted Protection Post-Surgery is very important. It helps keep you safe when you are less mobile, after your total hip or knee replacement surgery.
• Reduces risk of bleeding: The risk of bleeding is a concern for some patients. Normally doctors give adults a dose of 150 mg. Studies has shown that a dose of 110 mg is just as good at stopping clots. The good news is that it also reduces the risk of bleeding inside the body or in the stomach.
• Suitable for use in aged people: It gives a safer and very effective choice, for patients aged 75 to 80 and older. They have blood vessels and a higher risk of bleeding problems.
• Suitable to people with reduces kidney functioning: The 110 mg dose is a choice for patients with mild or moderate kidney problems. This way people with kidney issues can take a blood thinner without worrying that the medicine will build up to levels in their body.

Drug Interactions:

With other medicines that increase the risk of bleeding:

There are some medicines, which can interact with Pradaxa and cause your blood to thin excessively increasing the risk of internal bleeding. These medicines are-

• Other anticoagulants like warfarin
• Other antiplatelet medicines like Aspirin
• NSAID pain relievers like Ibuprofen, Naproxen
• A few types of anti-depressants like Fluoxetine and Sertraline

Pgp inhibitors:

Since Pradaxa relies on transportation protein P-glycoprotein for absorption, medicines inhibiting Pgp can directly interact increasing the risk of Pradaxa’s toxicity in your blood. These medicines are-

• BP medicines like Amiodarone and Verapamil
• Antifungals like itraconazole, and Ketoconazole

Pgp inducers:

Some medicines increase the action of P-glycoprotein which lets Pgp absorb Pradaxa faster, thus reducing its effects in your body. Such pills are-

• Ant seizure pills like Carbamazepine
• Rifampin an antibiotic
• John’s Wort

Side Effects:

• Nausea: If you feel dizzy, talk takes it after food, but if you have severe nausea consult with a doctor.
• Anaemia: this is a severe side effect of taking Pradaxa and in this case, the doctors may abruptly tell you to stop using the medicines.
• Diarrhea: may occur if the patient is taking medicine sin an empty stomach.
• Frequent bruises, skin tenderness: Talk to doctor right away, as you may need to use a smaller dose.

Precautions and Warnings:

• Do not Stop Suddenly: Stopping Pradaxa without your doctor’s clear advice puts you at a risk of blood clots or stroke. Pradaxa leaves your system in 24 to 48 hours; if you quit taking it your protection, against clots goes fast.
• Spinal epidural hematoma risk: There is a risk of a blood clot, in the spine if you need a spinal tap, spinal anaesthesia or an epidural while taking Pradaxa. This blood clot can put pressure on your cord and cause paralysis that lasts a long time or is permanent. Your doctor needs to plan when to remove any spinal catheters and when to give you Pradaxa.
• Limit Alcohol: Heavy drinking or binge drinking can really up your chances of getting stomach ulcers and internal bleeding. Alcohol also affects your balance making you more likely to fall and hurt your head or joints, which can lead to blood clotsblood clots.
• Activity Caution: Avoid contact sports. activities where you might fall and hurt your head. Doing such, as skiing or horseback riding is risky and can lead to internal bleeding if you hit your head hard. If you had such an accident and in case you are not bleeding, see a doctor right away.
• Pregnancy: We do not have a lot of information about the safety of Pradaxa for women. Pradaxa should only be used when you are pregnant if it is necessary for your health and the good it does is more important than the risk it could pose to the baby. If you want to get pregnant or you find out you are pregnant you should tell your doctor away, about the Pregnancy and Pradaxa.
• Breastfeeding: We do not know if dabigatran gets into breast milk. Women should not breastfeed their babies when they are taking this medicine because it might hurt the baby. The safety of the baby is a concern when the mother is taking dabigatran. Therefore, breastfeeding is not an idea when you are taking dabigatran.

When Not To Use:

• Mechanical heart valves: If you have recently undergone a surgery for a damaged heart valves replaced with mechanical valves using Pradaxa is unsafe. Studies show that it can increase the risk of heart attack and stroke.
• Internal or external bleeding issues: If you have a condition, where your body is suffering from internal bleeding using this medicine is not safe at all. Examples of such conditions include having brain haemorrhage and stomach bleeding. Along with this, if you have suffered external bleeding recently as if you have a major wound that is still recovering using Pradaxa is not recommended.
• Severe kidney failure: Almost 8 0% of the drug is released from the body filtered out by the kidneys. If your kidneys are not functioning properly then this can lead to toxicity of Pradaxa in your body. This is why the doctors may not recommend it to patients with severe kidney impairment or kidney damage.
• Allergic reactions: If you are already allergic to the generic element of the medicine, which is Dabigatran Etexilate, using Pradaxa is unsafe. Deliberate use can lead to difficulty breathing, rashes or hives and swelling of the face and throat.

Storage And Disposal:

Store the Pradaxa 110 mg pills in the normal room temperature only avoiding direct sunlight and highly humid conditions. Dispose the sachet of the medicine safely after use and avoid using leftover medicines if it is past the expiry date.

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