Mikacin Injection (Amikacin)

Last Updated on 05/21/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What Is Mikacin Injection?

Mikacin Injection is an antibiotic injection that contains Amikacin, an aminoglycoside antibiotic used to treat serious bacterial infections.

It is commonly administered in hospitals or clinics under medical supervision.

Mikacin injection is a contains a generic antibacterial medication in it by the name of Amikacin.

This injectable antibiotic vaccine is only given in case of some serious bacterial infections and disorders in the patient when other antibacterial medicines become ineffective.

In addition, it is also given to patients who are currently not able to swallow an antibacterial pill, as they are hospitalized or have a serious health condition. It is used to treat-

• Blood infections like sepsis and Bacterial Infections
• Respiratory infections like pneumonia
• Stomach infections like peritonitis
• UTIs
• Bone infections like osteomyelitis
• Brain and spinal cord infections, like meningitis

Manufacturer

Aristo Pharmaceuticals Pvt Ltd is the company that manufactures the Mikacin injection.

Composition

✓ Active ingredient:

Amikacin sulphate is the core generic element inside the vaccine.

✓ Appearance:

Colourless to pale yellow, available in Type 1 glass vials (ampules).

Onset Of Action

✓ Immediate Action:

After applying the injection, the absorption time of the composition in your body begins in 20 to 30 minutes.

The first effects of the injection are a reduction of itching, burning, and other symptoms. Issues like swelling also slowly reduce within the first few days of use.

✓ Visible Improvement:

Visible signs of improvement generally come up within a week of use.

Method Of Use Of Mikacin Injection

✓ Intramuscular injection:

Get the skin ready by washing the affected area with water and drying it so that it is perfect for skin application.

It is then injected into one of the core muscles of your body, such as the thigh, buttock, or arms.

✓ Intravenous infusion:

For hospitalized patients in an unconscious state, the medication is directly administered into the vein using a saline dextrose solution.

Mechanism Of Action Of Mikacin Injection

Mikacin Injection works by stopping bacterial growth. It blocks bacterial protein synthesis by binding to the 30S ribosomal subunit, which prevents bacteria from producing essential proteins needed for survival.

✓ Penetration of the Cell Wall:

Before the drug starts to work, it has to get inside the cell. Amikacin molecules go through the membrane of Gram-negative bacteria using special channels called porins.

✓ Binding to the Ribosome:

Specifically, Amikacin binds irreversibly to the 30S ribosomal subunit.

✓ Disruption of Protein Synthesis:

Blocking Initiation stops the ribosome from starting to read the code. The ribosome gets confused and reads the mRNA sequence wrongly.

This results in the creation of proteins that do not work. The protein chain is cut off early and is not finished. This happens because the ribosome stops working soon on the protein chain.

✓ Cell Death:

The accumulation of these faulty, abnormal proteins is what ultimately kills the bacteria.

Mikacin Injection- How Long Does It Last?

✓ Standard Course:

The treatment for the Standard Course usually takes around 5 to 10 days.

✓ Elimination:

After giving the last dose, its effects are eliminated from your body within 15 hours.

✓ Improvement Window:

When you use the treatment, you will see improvement in your skin within 3 to 5 days.

Dosage

✓ One-time daily dose:

The doctors administer the vaccine only one time per day in this schedule. The standard dose is around 15 mg per kg of body weight of the patient.

✓ Divided dosage:

In some patients, doctors recommend dividing smaller doses at fixed intervals. The standard dose is 7.5 mg per kg of body weight given every 12 hours or 5 mg per kg of body weight given every 8 hours.

✓ What Happens If I Overdose On This Medicine?

Excess administration of the vaccine can lead to severe side effects, including kidney disorders.

✓ What Occurs If I Miss Taking A Dose?

Missed doses often, every few days, can result in no healing of the infection. Recent studies show that the inconsistent dose actually makes the bacteria tolerant to the medication.

Benefits Of Taking Mikacin Injection (Serratiopeptidase) Pills

✓ Symptoms Relief:

Relief from symptoms such as redness, swelling, itching, and crusting of skin.

✓ Fast Recovery from Wounds:

Faster recovery and preventing complications of cuts and wounds.

✓ Mental relief:

It helps you to get rid of the anxiety or the stress that results from irritation, itching, and swelling of the skin.

Drug Interaction Classification

✓ Live Vaccines:

Like those used to treat cholera, or other vaccines like BCG or treating typhoid.

✓ Neuromuscular Blockers:

Amikacin can make drugs like Cisatracurium work stronger.

✓ Anticoagulants:

Taking Warfarin interacts with Mupirocin, increasing the chances of internal bleeding.

✓ Local Anesthetics:

Using Benzocaine, Lidocaine or Prilocaine with Amikacin might increase the risk of methemoglobinemia.

✓ Bromhexine:

The medication Bromhexine can make the body get rid of Amikacin faster. This means that Amikacin may not work well as it should when you take Bromhexine at the same time.

Excretion Enhancers like Bromhexine can increase the rate at which the body gets rid of Amikacin and make it less effective.

Precautions Before Starting A Dose Of Mikacin Injection

✓ Allergy:

Polyethylene glycol is present inside this, which is allergic to a few people. Tell it to the doctors if you have the same issue.

✓ Kidney Disease:

Using Mupirocin with severe kidney disorders, like kidney failure or when undergoing dialysis, can result in additional complications.

✓ Other Health Issues:

Let your doctor know if you have had stomach or intestine problems, like colitis. Antibiotics can sometimes cause diarrhea.

Safety Advice:

✓ External Use Only:

You should never put this on the inside of your eyes, nose, or mouth. If you accidentally get some in your eyes, you need to rinse them away with a lot of cold water.

✓ Do Not Double Dose:

If you forget to apply the injection, you should put it on as soon as you remember. If it is almost time for your dose, you should skip the one you missed. Do not put an injection to make up for the missed dose.

✓ Allergic Reactions:

Allergy to glycol or Mupirocin can bring up rashes more severe or cause skin irritation and even skin peeling.

✓ Secondary Infections:

Using the injection for more than 10 days can cause too much fungus to grow in your body, like yeast infections.

✓ Lifestyle & Hygiene:

You should be careful not to let the tip of the Mikacin injection tube touch the skin or any other surface. This way, with the Mikacin injection medicine, inside the tube, I will stay sterile.

✓ Breastfeeding:

To avoid the nipple from being swallowed by your baby, you should wash the nipples carefully if applying them to the region.

When To Seek Medical Help?

✓ Lack of Improvement:

If you have a skin infection, you should talk to your doctor if it does not get better in days. If the skin infection is getting worse and spreading to other parts of your body, you should talk to your doctor.

If the skin infection becomes a lot more painful or the area around it becomes very red or swollen, you should consult your healthcare provider about your skin infection.

✓ Rare Systemic Side Effects:

If you use this on your skin and something bad happens, you should go ask for help. If you get loose or bloody stools, even a long time after you stopped using it, it’s because sometimes the medicine can cause big problems in your intestines.

✓ Signs of Kidney Issues:

If you already have kidney problems and you put the injection on an open cut, you should pay attention to how often you go to the bathroom.

Storage Instructions

• Store below 25–30°C
• Protect from moisture and direct sunlight
• Keep out of reach of children

Where To Buy Mikacin Injection In Australia?

You can now buy the Mikacin injection in Australia and other variants of Mupirocin on the licensed online pharmacy AustraliaRXMeds.

Get additional discounts and fast delivery from the store.

Conclusion

Mikacin Injection is a powerful antibiotic medication used to treat serious bacterial infections in different parts of the body.

It contains Amikacin, which works by stopping the growth of harmful bacteria and helping the body fight infection effectively.