Bendex 400 Mg (Albendazole)

What Is Bendex 400 Mg?

Bendex 400 Mg is a pill, which you normally take to treat worm infections inside your body. This medicine treats different types of infections caused by worms affecting the stomach and the intestines. It is a prescription pill, which needs a suitable dose depending on type and suitability of the infection so always consult with the doctors.

➯ Brand Manufacturer:

The original brand manufacturer of Bendex 400 mg is Cipla Ltd.

➯ Composition and Appearance:

• Active Component: Albendazole IP (400 mg). “IP” means that the Albendazole has been purified according to the regulations of the Indian Pharmacopoeia, the set of guidelines regulating drug quality in India.
• Inactive Components: In order to produce a chewable tablet with a pleasant taste and without unpleasant chemical flavours, the tablet is made using binding agents, disintegrating agents, and a flavour and a sweetener.
• Packaging: The reason that the recommended adult dose of the drug is a one-time use medication is why the Bendex 400 Mg comes in a small compact pack of exactly 1 tablet only.
• Shape: It is round and solid in shape and can be easily chewed.
• Colour: Based on the particular batch of tablets, their flavours (for example, strawberry flavouring) can make them light pink/off-white coloured.

➯ Time Of Action:

1. Against Intestinal Parasites (Local Action):

If you have ordinary gut parasites such as roundworms, hookworms, or pinworms, then the medication starts to work right away after it enters the intestinal tract.

2. For Tissue and Brain Infections (Systemic Action)

In case of infecting affecting brain tissues like neurocysticercosis and hydatid cysts, the medicine intake allows metabolism in the liver and absorbed in the nervous system.

• Peak Level: The maximum concentration of the active form is reached in your blood plasma and tissues in 2 to 5 hours.
• Food factor: The intake of Bendex along with a fat-containing meal causes the drug’s absorption to rise by up to five times, greatly boosting its action on the target tissues.

How Bendex 400 Mg Works?

• Destruction of the Cell’s “Skeleton” Structure: In the normal cell functioning, this protein forms polymerized structures called microtubules that function as tiny conveyor belt structures for the worm’s cells. Bendex 400 Mg completely inhibits these functions.
• Deprivation of Glucose: Glucose is the energy fuel that the worm uses to survive, travel around, and reproduce. Without any sugar source, the worm resorts to exhausting its internal energy store, which consists of glycogen.
• Paralysis and Death: As the worms’ energy runs out, they will no longer be able to move their muscles. The worms become paralysed and will be unable to resist the muscular movements of your intestines, or cling to them.
• Natural Elimination: The worms will then be dead or have stopped moving; at which point, your digestive system automatically takes charge.

Dosage Of Bendex 400 Mg:

There is a strict control over use of Bendex 400 Mg which is recommended by the doctors after diagnosing the infection and its severity.

• Adults and children over 2 years: Given as a single dose of 400 mg.
• Repeat usage: A doctor can tell you to repeat a single dose of 400 mg in case of pinworm infections after 14 days to kill any newly hatched eggs before they mature enough to reproduce.

➯ Advantages Of Bendex 400 Mg:

• Wide Range Effectiveness: Each dose of Bendex 400 Mg is highly effective against different types of worms.
• Get rid of gut symptoms: While full treatment takes 2 to 3 days the patient can get relief from gastric symptoms like vomiting, stomach cramps.
• Avoids Development of Serious Health Problems: Just a single dose is enough to get rid of severe health complications in the end like anaemia, weight loss, and intestinal obstruction.

Drug Interactions:

• Drugs causing rapid Bendex toxicity: These medicines prevent rapid elimination of Albendazole from your body.
  • Cimetidine for acid reflux
  • Dexamethasone a steroid
  • Praziquantel another anti-parasitic drug
• Drugs that reduce Bendex effects: These drugs can actively metabolize the drug meaning that eventually it leaves your body much faster and thus shows very little effects. It includes medicines from the anti-convulsing group of pills such as-
  • Phenytoin
  • Carbamazepine
  • Phenobarbital
• Drugs Affected by Bendex:
  • Theophylline for asthma and COPD
  • Blood Thinners like Warfarin

Side Effects:

Common Side Effects:

• Nausea: this side effect is mostly short-lived, and you should always consult with a doctor.
• Vomiting: Occurs when you take the medicine without food.
• Stomach pain: Mostly occurs when the matured worms die causing irregular gut movements but may occur if you take the medicine in an empty stomach.
• Mild diarrhea: Can occur as the dead worms and immature larvae transform composition of stool. You need to consult with a doctor before taking a medicine for it.

Severe Side Effects:

• Headaches or dizziness: It is a general indication of the drug being present in your nervous system. It is better to take rest and consult with a doctor if it gets worse.
• Temporary Hair Loss (Reversible): Usually occurs when you keep taking doses for several weeks.
• Fever: Sometimes, there may be a slight fever, resulting from the dying of the parasites.

Precautions and Warnings:

1. Pregnancy and Fertility (High Risk)

• Birth Defects: This drug may cause very serious deformities during pregnancy. The use of this drug is completely prohibited when pregnant.
• 2 Week Rule: In case if you are a reproductive age woman, take the Bendex treatment at least two weeks after a negative pregnancy test and in the first seven days of your period.
• Contraception: Contraception must be used effectively during the use of the medication and will have to be done so for at least one month after your last dose.
• Breastfeeding: There are no accurate data as to how much of the medication enters the breast milk. Consult your physician regarding the potential risk as stopping breastfeeding may be recommended.

2. Liver Health and Blood Tests

• Liver function tests: Bendex metabolizes in the liver so if you have any major liver infections it may not be absorbed by the liver due to low liver enzymes like bile leading to toxicity of the medicine in your body. This is specifically true in case of patients suffering from jaundice, and liver failure disorders.
• Complete Blood Count (CBC) Tests: Use of Bendex for a long time leads to reduction of bone marrow formation leading to reduction of WBCs. You need to have CBC test done before taking the medicine.

Conditions In Which It Is Contraindicated:

1. Pregnancy: The doctors will ask the female if she is pregnant or trying to get pregnant. Remember that Bendex may cause harm to the foetus and cause malformations or even death. Remember to clearly tell the doctors if you are trying for pregnancy.
2. Allergy: There is totally no need to use Bendex 400 mg if you are allergic to the generic substance Albendazole. Remember that if you know about such allergic cases in the past you should tell it to the doctors right away. In case of desperate use, it can lead to side effects like-

• Rashes on skin
• Inflammation
• Difficulty breathing

3. Active or Severe Liver Disease: The reason why it is not recommended due to a severe liver disease is that it can lead to drug toxicity. A poor liver function means that the drug is not processed by your liver well, which can increase the effects of the medicine a lot.
4. Untreated Retinal Parasites (Eye Infection):

• Reason: If the patient’s eye harbours parasitic larvae (neurocysticercosis that has damaged the retina), Bendex 400 Mg is effective to eliminate worms in situ. However, the inflammation caused by the dying parasitic worms can lead to irreversible retinal damage or even blindness.
• Contraindications: Do not administer Bendex for parasites living in tissues before performing an extensive eye exam.

Storage and Disposal:

The drug Bendex 400 mg needs to be kept in a cool and dry area where the temperature is lower than 30 degrees Celsius. Avoid direct sunlight contact and preferably keep it at low humidity areas.

Where To Buy Bendex 400 Mg In Australia?

There are many pharmacies both online and offline selling Bendex 400 mg. One such online licensed pharmacy portal is AustraliaRXMeds.