Amicline 500 Mg

Last Updated on 06/26/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What is Amicline 500 mg?

Amicline 500 mg is an antiprotozoal pill, which is given for the treatment of intestinal Amoebiasis. This medicine also helps relieve symptoms of gut infections, such as stomach cramps, flatulence, bloating, and dysentery.

The active ingredient in the medicine is Diloxanide Furoate, which belongs to the luminal amebicide group.

Manufacturer

Franco India Pharmaceuticals Pvt. Ltd. is the company which is the manufacturer of Amicline 500 mg pills in India.

Appearance: Each pill is an uncoated solid tablet with round and smooth edges.

Onset of action

• Beginning of absorption: It usually takes Amicline about 30 to 60 minutes to initiate its action.
• Peak levels: When you take the medication, it gets into your bloodstream quickly. The medication reaches its level in your blood within 2 hours.
• Total duration: A single medicine lasts in your body, showing its effects for up to 6 hours.
• Relief from symptoms: the infection begins within 24 to 48 hours of taking the medicine.

Note: Amicline 500 mg exactly as prescribed by your doctor and complete the full course of treatment, even if your symptoms improve before the medication is finished.

How does Amicline 500 mg work?

Amicline 500 mg tablet targets the parasite Entamoeba histolytica inside the large intestine in the space called the lumen.

It works locally inside the guts rather than being activated in the bloodstream, which is why it is called a luminal amebicide. It targets the trophozoites, which are the multiplying amoeba in the guts.

It blocks several vital metabolic functions of the amoeba by inhibiting the production of certain proteins needed for glucose processing.

Without being able to take glucose and convert it into energy, the amoeba essentially dies.

What are the benefits of Amicline 500 mg?

Kills both active and dormant cysts of amoeba

Amicline 500 mg is a medicine that works by actively multiplying trophozoite amoeba, and even the ones that are dormant in the body. This helps you to get a complete and avoid any chances of recurring infection.

Highly targeted action

The medicine works locally in the intestines rather than being present in the bloodstream. This ensures a more direct action on the amoeba at the site of the infection.

Rapid relief from symptoms

Even though for a complete treatment you may need to take the medicine for 10 days, you can get relief from symptoms within 1 to 2 days of using the medicine on time.

Low risks of side effects

Since the medicine is activated and works only inside the intestines rather than being present in the bloodstream, there are little chances of having systemic side effects like drowsiness, toxicity, and so on.

Effective in the treatment of asymptomatic patients

The medicine works equally well in those patients who are carriers of the amoeba but do not actively show any signs of the infection.

Can you give me the dosage details of Amicline 500 mg?

Standard adult dose: Doctors recommend a dose of Amicline 500 mg to be taken 3 times per day for up to 10 days.

Maximum adult dose intake: Doctors recommend a maximum of 1500 mg or 1.5 gm divided into 3 doses of 500 mg per day.

Dose in children

• • Above 25 kg: Dose of 20 mg per kg of bodyweight is given in three different doses during the day for 10 days.
  • Under 25 kg: Children weighing less than 25 kg should not receive the 500 mg tablet.

With or without food: Doctors recommend that you always use Amicline 500mg for yourself or your child only after a meal.

👉 Doctors generally recommend taking Amicline 500 mg with or after meals to help reduce stomach irritation and minimise gastrointestinal side effects such as nausea, abdominal discomfort, and flatulence.

Method of use: Take it with water and avoid crushing or breaking the medicine in half when taking it.

Time intervals: Since you need to take three pills a day, it is better to keep a time gap of at least 8 hours between consecutive doses.

👉 Thus, you can take the medicines once each during the early morning, during the afternoon, and once at night.

What are the drug interactions of Amicline 500 mg?

Blood Thinners (Anticoagulants)

• The Risk: Taking things can make you more likely to get bruises or have internal bleeding.
• Action: If you are taking medicines that prevent blood clots, your doctor might need to keep an eye on your blood test results, such as your prothrombin time and INR levels.

Phenytoin (Anti-Seizure Medication)

High levels of Phenytoin can become toxic. When this happens, you might get confused, have trouble moving around or even get tremors, confusion, or loss of coordination.

Acid-reducing medicines like Cimetidine

Combining the effects of Amicline 500 mg with acid-reducing medicines like Cimetidine can potentially prolong the time for which the former lasts in your body, increasing the chances of drug toxicity.

Medications Affecting Blood Counts

• Clozapine
• Certain NSAIDs

Precautions and Warnings

1. The Alcohol Warning

While taking alcohol does not interact heavily with Diloxanide, similar to other antiparasitic medicines like metronidazole or tinidazole, it can cause a few mild issues like stomach cramps, indigestion, bloating and so on.

2. Blood Count Monitoring

A precaution to note is that if you are on this medication for a term immune condition, your doctor may recommend periodic Complete Blood Count (CBC) tests to monitor your overall health.

👉 Also, be aware that if you get a fever, sore throat, or chills, you should stop taking the medication and call a doctor right away.

3. Pre-existing Health Conditions

Liver Disease: The liver is very important because it breaks down this medicine. If your liver is not working well, the medicine can build up. Become toxic.

Kidney Issues: If your kidneys are not working as well as they should, you might need to take a smaller amount of the medicine.

Blood Disorders: If you have had problems with anaemia or low platelet counts, you need to be very careful when taking Amicline.

4. Pregnancy and Breastfeeding

Pregnancy: You should not take this when you are pregnant during the first few months. Your doctor will carefully weigh the potential benefits against any risks.

Breastfeeding:  This medicine can get into your breast milk. You need to talk to a doctor to see if it is safe for your baby.

⚠️ Warning: If you are pregnant or planning to become pregnant, use Amicline 500 mg (Diloxanide Furoate) only if prescribed by your healthcare provider.

When not to use Amicline 500 mg Tablet?

Hypersensitivity (Allergies): Do not take Amicline if you are allergic to Diloxanide, the generic element of the medicine or else you can get allergic reactions like-

• Allergic reactions on the skin
• Swelling in your face or throat
• Trouble breathing

Severe Liver or Kidney Impairment: The Amicline drug needs to be processed by the liver and filtered by the kidneys to be safe. If the liver and kidneys are not working well, the Amicline drug can become very toxic.

Existing Blood Disorders: Avoid the medicine if you have a medical history of-

• Low WBC count
• Bone marrow suppression
• Severe anaemia
• Low platelet count

Storage and disposal

Store the sachet of Amicline 500mg pills in low heat and humid conditions. Avoid storing in the fridge. For disposal, check expiry dates on the sachet.

Where to buy Amicline 500 mg in Australia?

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