Loceryl Cream

Last Updated on 04/11/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What Is Loceryl Cream?

Loceryl Cream is a topical antifungal medication used to treat fungal infections of the skin. It contains the active ingredient Amorolfine, which helps eliminate fungi and prevent their growth.

Follow the timing for use and inform about any other skin and dental infections, to the doctors first. Do not use any other anti-fungal ointment at the same time as taking the Loceryl Cream.

✓ Manufacturer

Galderm India Pvt. Ltd. is the manufacturer of the Loceryl Cream ointment.

✓ Composition

Amorolfine is the main antifungal substance of the ointment from the allylamine class of medications.

✓ Onset Of Action

• Activation: The drug begins absorption and releases the active ingredient of the ointment within 30 to 40 minutes of application.
• Half-Life: The medication reduces to half its original amount usually within 3 to 4 hours of activation.
• Peak Action: The action of the ointment usually peaks within 2 hours of applying the ointment.

Mechanism Of Action Of Loceryl Cream

Loceryl Cream contains Amorolfine, a broad-spectrum antifungal agent. It works by disrupting the structure and function of fungal cell membranes, leading to the death of the fungus.

✓ How It Works Step-by-Step

1. Inhibits Ergosterol Synthesis

• Amorolfine blocks key enzymes involved in producing ergosterol
• Ergosterol is an essential component of the fungal cell membrane

2. Weakens Fungal Cell Membrane

• Without ergosterol, the membrane becomes unstable and defective
• This causes leakage of important cell contents

3. Stops Fungal Growth

• Fungi lose their ability to grow and multiply
• Eventually, the fungal cells die off

Loceryl Cream: How Long Does It Last?

The duration of the effect of Loceryl Cream (Amorolfine) depends on the type and severity of fungal infection, but it is known for providing long-lasting antifungal action on the skin after each application.

✓ Total Treatment Duration

Depends on infection type:

• Athlete’s foot: ~2–4 weeks
• Ringworm / Jock itch: ~2–6 weeks
• Skin fungal infections (general): until symptoms clear + a few extra days

In some cases, doctors may recommend continuing treatment for 1 week after symptoms disappear

Recommended Dosage Guidelines Of Loceryl Cream Ointment

✓ Standard Dosage (Adults)

• Apply a thin layer once daily
• Gently rub into the affected area and surrounding skin

✓ Duration of Use

• Athlete’s foot: 2–4 weeks
• Ringworm / Jock itch: 2–6 weeks
• Other skin fungal infections: until symptoms clear + 7 additional days

✓ For Children

• Antifungal creams like Loceryl cream are generally recommended for children if their age is more than 6 years.

✓ Dose As Per Body Weight

• Less than 30 kg: 125 mg dose 1 time per day
• 30 to 40 kg:5 mg dose 1 time daily
• More than 40 kg: Usually the same as the adult dose given 1-2 times per day.

✓ What Occurs If I Overdose On This Ointment?

Never try to increase the amount of application or frequency of using Loceryl Cream antifungal for a faster remedy, as it can cause many side effects.

✓ What Occurs If I Miss Taking A Dose?

Frequently missing your dose on time may not help treat the infection at all. Remember that the consistent action occurs only after 5 to 7 days of using the ointment. Frequent breaks in your dose will disrupt the consistent action of the drug.

Clinical Benefits Of Loceryl Cream

Loceryl Cream is a topical antifungal that provides effective treatment for superficial fungal skin infections by directly targeting the fungus at the site of infection.

1. Broad-Spectrum Antifungal Action

• Effective against multiple fungi, including dermatophytes, yeasts, and moulds

Helps treat common skin infections like:

• Athlete’s foot
• Ringworm
• Jock itch

2. Fungicidal + Fungistatic Effect

• Stops fungal growth (fungistatic)
• Kills fungi at higher concentrations (fungicidal)
  Ensures strong and lasting infection control

3. Direct Action on the Infection Site

• Applied directly to the affected skin
• Delivers high local concentration with minimal systemic absorption
  👉 Reduces risk of body-wide side effects

4. Rapid Symptom Relief

Helps reduce:

• Itching
• Redness
• Scaling
• Irritation

5. Prevents Recurrence

• Continuously working in skin layers for a prolonged period
• Helps reduce the relapse of fungal infections

6. Easy and Convenient Use

• Simple once-daily application
• Suitable for routine home treatment

Side Effects

Mild Issues

✓ Headache, Dizziness:

Occurs more if you take the ointment on an empty stomach or when your body is dehydrated. So, avoid using the ointment on an empty stomach and have frequent water intake.

✓ Fatigue:

Sit or lie down for a few hours and avoid heavy work.

✓ Dry mouth:

Using an antifungal ointment can cause dryness in your mouth, so keep taking water in small sips.

✓ Skin dryness:

Talk with a doctor if you find mild skin dryness, and stop using the cream further if your skin is so dry that it starts to peel off.

Severe Issues

• Blisterson then skin: This is a very severe side effect, and you need to stop using the Loceryl cream further.
• Persistent diarrhoea: It generally indicates that the patient is unable to adjust to the dose, so reduce daily intake.

Drug Interactions Of Loceryl Cream Ointment

✓ Drugs that can get toxic:

Loceryl Cream can prolong the action of such ointments and reduce their clearance from your body, making it toxic.

✓ Antidepressant:

SSRIs and TCAs with a composition of amitriptyline, nortriptyline, and fluoxetine.

✓ Beta blockers:

With a composition of Metoprolol and Propranolol, usually taken for low BP.

✓ Anti-Arrhythmia:

Ointments for arrhythmia, like flecainide and propafenone.

✓ Antipsychotics:

Risperidone, haloperidol.

✓ Other medicines that reduce their effects:

Tamoxifen for cancer treatment

Painkillers like codeine and Tramadol

✓ Medicines that reduce the action of Loceryl Cream:

Rifampicin an antibiotic

Cimetidine for stomach ulcers

Precautions Before Starting A Dose Of Loceryl Cream Ointment

✓ Disclosing certain health issues:

Use of the Loceryl Cream may not be safe if the patient has certain other health issues, like-

• Kidney infections
• Liver disorders
• Low hormonal levels
• Heart problems
• Severe diabetes

✓ Avoid using for certain skin issues:

The doctors may adjust the dose if the patient already has some skin disorders, as given below, and uses ointments for them-

• Hives
• Rashes
• Insect bites

Safety Advice Of Loceryl Cream

✓ Pregnancy:

Studies show that although no major interaction was found, use of a high dose might not be safe. Neither is it safe to use the ointment for a longer tenure in such cases.

✓ Breastfeeding:

In 2018, the TGA scientists found that traces of Amorolfine were found in the breastmilk of mothers after studying it. Thus, use of the dose may not be safe if you have an infant who is very dependent on your milk. Tell the doctors about it in advance.

✓ Addictions:

Use of any additives in the end is going to make the action of the Loceryl Cream less effective. Studies show that it may also increase the chances of many side effects.

✓ Driving:

Even though no major interaction has been found, do not drive if you get a headache or feel dizzy or restless after taking the ointment.

When To Seek Medical Help?

✓ Allergic Reactions:

For signs of any allergic reactions on the body, like swelling, rashes, blisters or swelling of the mouth and lips.

✓ Jaundice:

For signs of jaundice, such as yellowing of skin and urine.

✓ Other Side effects:

For any kind of persistent or severe side effect.

Storage And Disposal Guidelines

✓ Storage Guidelines

• Store at room temperature (below 25°C)
• Keep away from direct sunlight and heat
• Do not freeze the cream
• Store in a dry place, away from moisture
• Keep tightly closed after every use
• Keep out of reach of children and pets

✓ Disposal Guidelines

• Do not flush into the toilet or sink
• Do not throw household waste without precautions
• Prefer pharmacy return or take-back programs if available

✓ Dispose of the tube if:

• Expired
• No longer needed
• Contaminated or damaged

Where To Buy Loceryl Cream In Australia?

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You can order Loceryl Cream online from pharmacies. Make sure you only buy from verified and licensed sources to ensure authenticity and safety.