Midotab 5 Mg

What Is Midotab 5 Mg?

Midotab 5 mg is a prescription medication primarily used to treat severe orthostatic hypotension—a condition where a person’s blood pressure drops significantly and suddenly when they stand up from a sitting or lying position. This drop often leads to symptoms like severe dizziness, light-headedness, blurred vision, or fainting.

➯ Who Makes Midotab 5 Mg?

JB Pharmaceuticals Ltd in India makes Midotab 5 mg and all other dose variants of this brand name.

➯ What Is The Composition And Appearance Of Midotab 5 Mg?

• Chief generic element: The active substance present in Midotab 5 mg is Midodrine Hydrochloride.
• Excipients: Along with the chief generic element, there are a few other inactive substances present in the medicine like binders, fillers, and Disintegrants.
• Appearance: Each pill is light to reddish pink in colour with a circular rounded shape and comes in the form of an uncoated tablet.

➯ Onset Of Action For Midotab 5 Mg In Your Body

• Initial effects: The beginning of effects starts within 30 to 45 minutes of taking the medicine.
• Peak effects: For the drug to reach its maximum working effects, it will need about 1 to 2 hours.
• Lasting action: Each medicine is roughly active inside your body for up to 3 to 4 hours.

How Does Midotab 5 Mg Work?

• Drug activation: The drug after intake releases the active compound Midodrine but this is dormant until it reaches the liver and turns into its active desglymidodrine.
• Binding with Alpha-1 receptors: This active drug substance then binds with the alpha one receptor in the muscle walls of the arteries and veins.
• Vasoconstriction effects: After binding to these alpha one receptor in the tissues, it signals the muscle tissues to vasoconstrict or get narrow.
• Counteracting gravity: The narrowing of the pathways increases the pressure of the blood flowing inside and this prevents the blood from pooling or being trapped in the legs, or thighs.

Dosage Of Midotab 5 Mg:

• Starting dose: Sometimes the doctors can recommend you begin with the smaller Midotab 2.5 mg dose. This means that you have to split a 5 mg tablet in half and take one-half of it.
• Standard maintenance dose: The standard maintenance dose is a single tablet of 5 mg each time taken three times a day.
• Maximum dose allowed: The doctors allow for a maximum of 10 mg tablet taken 3 times per day totalling the dose to be 30 mg.
• Dosage adjustments: Generally, a doctor can adjust the dose if you have renal disorders reducing your dose to 2.5 mg per use.
• Bedtime rule: Always take the last dose for your day a minimum of 4 hours before going to bed. Also, remember to sit upright after taking the medicine and do not lie down.

When To Use Midotab?

Since you have to take three doses during the entire day, the doctors structure these three pills during-

• 1 in the morning time right after getting up from bed
• 1 later in the day during noon
• 1 during evening hours

Benefits Of Taking Midotab 5 Mg:

• Avoids dizziness and light-headedness
• Reduces sudden fainting in patients with orthostatic hypertension
• Gets rid of other signs of low BP like blur vision, fatigue, brain fog
• It can also be used in patients suffering from low BP due to autonomic disorders like Parkinson’s disease

Drug Interactions With Midotab 5 Mg

• With other vasopressors and decongestants: Avoid using other medicines like pseudoephedrine, Phenylephrine that also constrict blood vessel as they can cause sudden spikes of BP.
• Fludrocortisone: When used together it can increase the risk of supine hypertension that is high BP when you are plying down.
• Beta-blockers: Avoid use of medicines, which slow down the rate of heartbeat like digoxin, Metoprolol, and atenolol, which can cause heartbeat to drop to severely low levels.
• Alpha-blockers: Medicines like Prazosin, Tamsulosin, can completely cancel out the effects if Midotab 5 mg as they help raise BP.
• TCAs and MAOIs: Antidepressants like Amitriptyline and Phenelzine can also cause dangerous spike in BP.
• Thyroid medicine: Medicines with Levothyroxine can increase sensitivity of Midotab for the heart causing irregular heartbeat and high BP.
• Enzymatic inhibitors: Midodrine is broken down to its active form by the liver enzyme CYP2D6. Any medicine that reduces effects of this enzyme like Fluoxetine, paroxetine, and Bupropion can reduce effects of Midotab in your body.

Precautions And Warnings When Taking Midotab

• Do not lie down on bed after taking the medicine: If you lay down on bed there is a side effect by the name of supine hypertension, which is sudden spike of high BP, which occurs. This can even cause other signs like chest pain or a sudden goose bump inside.
• Last dose at least 4 hours before bedtime: Remember to take your last dose a minimum 4 hours before sleep. This helps avoid supine hypertension effects.
• BP monitoring regularly: You have to regularly monitor your BP levels at home and note them down. Take two measurements one when standing and other when lying flat.
• Keep checking your pulse often: Midotab tablets can sometimes overwork resulting in reducing the heartbeat. Make sure to check your pulse a few times during the day.

When Not To Use Midotab 5 Mg?

• With existing health issues: With major heart disorders, already doctors may not recommend taking this drug at all.
  • With severe kidney disorders as the drug is flushed out of your body through the kidneys.
  • With prostate disorders, it can cause urinary blockage.
  • With diabetes that are more prone to having sudden BP spikes.
• When pregnant or breastfeeding: The effectiveness of Midotab 5 mg has not been established OT studied in pregnant or breastfeeding mothers. It is always a good idea to talk with your doctor before suddenly beginning with an abrupt dose.
• When having severe side effects: If you are having severe or less common side effects like headache, nausea, heartburn, flushing, sudden chest pain consults with the doctors and stop taking further doses.
• If you are allergic: Do not use the drug if you are allergic to Midotab and its generic substance Midodrine hydrochloride.

Storage And Disposal Guidelines For Midotab 5 Mg

Store the Midotab 5 mg pills in an area of low humidity or else they can turn wet or soggy and out of direct sunlight heat in open-air room temperature conditions. It is best to store the medicine within 15 to 25 degrees Celsius range.

Dispose the empty sachets when you have taken all the medicines, or when it is past the expiry date. Make sure to keep checking the expiry date often.

Where To Buy Midotab 5 Mg In Australia?

To buy Midotab 5 mg pills in Australia you will need a recommended prescription from the doctors first. You will then be eligible to buy this medicine from local medicine shops near your home. For online users check out any online pharmacy such as AustraliaRXMeds.