Clofi 100 Mg (Clomiphene)

Last Updated on 06/16/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What is Clofi 100 mg?

Clofi 100 mg is a medicine that is given to treat fertility issues in a woman. The TGA in Australia found that it helps in conditions such as low levels of estrogen and progesterone that lead to a lack of proper ovulation cycles in women.

Manufacturer

Sunrise Remedies Pvt. Ltd. is the original manufacturer of the Clofi 100 mg tablet brand and all its dose variants.

Composition and Appearance

• Active ingredient: Clomiphene, a form of estrogen receptor modulator, is the chief generic element of the medicine.
• Appearance: It is a rounded to slightly oval tablet, which is white in colour.

Onset of action

• Hormonal onset: Within the first 3 to 5 days, regular use of the medicine blocks the estrogen receptors in the brain, which increases FSH and LH hormones for egg development.
• Time for Ovulation: Ovulation usually begins within 5 to 10 days of completing the course and taking the last medicine.

How does Clofi 100 mg work?

Blocking Estrogen Receptors

Clofi is classified as a SERM. It has a molecular structure highly similar to estrogen. Once taken, Clofi 100 mg pills act on estrogen receptors located in the hypothalamus.

Low Estrogen Levels

Because of blocking the receptors, the brain wrongly thinks that your body’s estrogen level is critically low. During a normal period of menstruation, when estrogen levels are low, it means it is time for the body to develop an egg.

Initiating the Hormonal Cascade

To counteract this alleged deficiency, the hypothalamus secretes GnRH. GnRH directs the pituitary gland to produce an excessive amount of two important reproductive hormones:

• • Follicle Stimulating Hormone (FSH): This hormone stimulates the growth of the ovaries and maturation of fluid-filled sacs known as follicles, which contain the eggs.
  • Luteinizing Hormone (LH): It assists in the development of follicles and eventually initiates the release of the egg from the ovary.

Development of Follicles and Ovulation

In response to increased FSH and LH, the follicles in the ovaries produce elevated levels of actual estrogen. When the follicles become fully mature, there is a natural spike in the level of LH, leading to the rupture of the follicle and subsequent release of the egg (ovulation).

Dosage

For mild infertility issues

• • Take the Clofi 100 mg pills one time daily for 2 to 3 weeks.
  • Start taking the medicine at least 2 to 3 weeks before the start of your ovulation cycle.

For severe issues

• • Use the Clofi 100mg one time only a day after a meal or on an empty stomach for 3 to 6 months.
  • For severe issues, the doctors can tell you to use two pills for two pills to use daily for 6 to 8 months.

Overdose

Avoid suddenly increasing the dose and remember that excess use puts you at risk of a few side effects.

Missed dose

Do not forget to take your medicine on time. Only with regular use is it possible to finally kill the bacteria causing the infection.

Available Strength

• Clofi 25 mg
• Clofi 100 mg

Benefits of taking Clofi 100 mg

High Success Rate for Ovulation Induction

When it comes to people who do not have regular ovulations (an ovulatory woman) or those who have irregular menstrual cycles, Clofi 100 mg will be extremely useful for them. Research indicates that about 70% to 80% of patients ovulate during the initial cycles of drug use.

Primary Choice for Polycystic Ovary Syndrome (PCOS)

This is one of the major reasons for female infertility among females; it is all because of the imbalance of hormones, where eggs can neither grow nor mature. Clofi 100 targets this condition, compelling the pituitary gland to produce the Follicle Stimulating Hormone (FSH).

 Ease of Oral Consumption and User-Friendly Nature

Clofi is not a sophisticated and expensive fertility treatment that demands daily injection administration (as is seen in cases of gonadotropin). Instead, an oral medication must be taken once a day over a short five-day period. As such, this medication regimen is simple and predictable for the patient.

Cost-Effective

When compared to ARTs such as In Vitro Fertilization (IVF) or Intrauterine Insemination (IUI), coupled with injectable medications, Clofi is extremely cost-effective. Using it helps patients make a cheaper try at conceiving than the subsequent expensive treatments.

Predisposing Supervised Pregnancy Attempts

In contrast to other medicines, Clofi helps women become pregnant by initiating ovulation at a defined period, normally five to ten days following the final medication intake. This way, healthcare professionals will easily determine when to engage in conception, sexual intercourse, or insemination.

Drug interactions

Interactions with Other Fertility Treatments

Gonadorelin/Gonadotropins (Injectable Reproductive Drugs): When Clofi is taken in combination with other very strong injectable reproductive hormones such as human chorionic gonadotropin (HCG) and follicle-stimulating hormone (FSH), there is a huge possibility of Ovarian Hyperstimulation Syndrome due to inadequate coordination between the treatments.

Letrozole/Aromatase inhibitors: Even when these two are sometimes switched around or even utilised under a completely different regimen for ovarian stimulation, the consumption of both medicines in uncoordinated ways may lead to hormonal fluctuations.

Ospemifene: The effect of estrogen receptors can be severely hampered and amplified by using them together with Clofi 100 mg tablets. At the same time, the use of both SERM’s is normally avoided.

Fluoroestradiol F-18: As Clofi acts on estrogen receptors, this radiopharmaceutical drug will not be able to bind effectively.

Interactions that Reduce Effectiveness

Hormonal Contraceptives (Oral Pills, Patches, Implants): The use of hormonal contraceptives simultaneously with Clofi produces an immediate clash between therapy and treatment. They are designed to produce opposite results, which makes them useless.

Estrogen-Based Treatments: Simultaneous use of estrogen-based drugs will act directly against Clofi at the receptor sites, preventing Clofi 100 mg from “fooling” the hypothalamus and thereby stopping the ovulation process.

Precautions and warnings

🤰🏻 Pregnancy: The FDA guidance and instructions for use of Clofi 100 mg in pregnancy are not safe, as it can harm the foetus or the developing baby in the uterus.

🤱🏻 Breastfeeding: Studies find it unsafe to use the medicine in case a female has an infant who is completely dependent on the breastmilk of the mother.

🗓️ Age guidelines: As per scientists at the NCBI, articles published on PubMed show that it is not suitable for teenagers or children, anyone below a minimum of 18 years of age.

💊 Addictions: Avoid taking any kind of addictive substance, as it results in causing more disruption in your hormones.

🚗 Driving: No, major interactions found, but still, the doctors may warn you if you get any headache or dizziness while taking the medicine.

What are the Side effects of Clofi 100 mg?

Common side effects

• Headache, Dizziness: Take a rest for a few minutes and drink water.
• Blur vision: Avoid doing any kind of major work where there is a chance of accident or injury.
• Fatigue: Mostly a temporary side effect that does not last more than 30 minutes.
• Drowsiness: Avoid taking it just after waking up in the morning.

Intense effects

• Sleepiness: If you notice severe sleepiness or fatigue, consult with the doctors.
• Unable to sleep at night: Sleep changes, especially sleep deprivation, are a severe issue where you to stopping taking the medicine.
• Flushing: Notice signs of warmth on the face, lips, and throat accompanied by mild fever, and consult with the doctors.
• Irregular bleeding: Any sign of irregular bleeding needs to be reported to the doctors immediately, and stop taking the dose.

When not to use?

In case of other health issues: Use of Clofi 100 mg is not safe as per doctors if the patient has other health issues like-

• • Other vaginal infections
  • Critical kidney disorders
  • Uterine cancer
  • Ovarian cancer

Having severe allergic tendency: Avoid taking it if you notice signs of allergic side effects, such as-

• • Flushing
  • Rashes or hives
  • Swelling of the throat and face

Storage and disposal guidelines

Avoid storing the medicine in a fridge or in conditions of high humidity and heat. Dispose of safely in a separate bag.

Where to buy Clofi 100 mg in Australia?

Buy Clofi 100 mg from only the Australian government’s online licensed pharmacy, which is Australiarxmeds. Get it online at the best price delivered right to your home.