Avanafil and Dapoxetine 80 Mg Australia

What is Avanafil and Dapoxetine 80 mg?

Avanafil and Dapoxetine 80 mg are a brand of medicine that combines the treat for ED or erectile dysfunction and premature ejaculation or PE both in adult males. Avanafil and Dapoxetine are the combination of generic elements inside each pill.

The mode of action for this medicine in case of ED increases flow of blood to the penis tissues, a form of action, which the scientists refer to as dilation of penis arteries. While the other way around it also increases the action of serotonin hormone and prevents its reuptake.

➯ What is Avanafil and Dapoxetine composed of?

Active ingredient: Each pill has a combination of generic elements with strength as given below-

• Avanafil 20 mg, a PDE-5 hormone inhibiting ingredient to boost erections.
• Dapoxetine 60 mg, which inhibits the reuptake of serotonin hormone to delay ejaculation.

Excipients: Along with these two substances, the drug contains a few binders to bind the medicine and fillers used to give volume to the pill.

➯ Who manufactures Avanafil and Dapoxetine?

Different manufacturers use the combination of 80 mg Avanafil and Dapoxetine to manufacture their own brands in India.

➯ What is the Onset timing for Avanafil and Dapoxetine?

• Drug absorption: Absorption of Avanafil usually begins within 30 minutes of intake and 1 hour for Dapoxetine.
• Peak plasma levels: Avanafil reaches its peak level in your blood within 60 minutes whereas for Dapoxetine the peak plasma levels occur after 2 hours of taking the medicine.

How does Avanafil and Dapoxetine 80 mg Work?

Avanafil

• Activation and inhibition of PDE-5 hormones: It releases the action of its generic element Avanafil inside your blood stream. Here it inhibits the PDE-5 hormones and increase the amount of cGMP enzyme.
• Activation of nitric oxide: This action is crucial to increase the working of nitric oxide that dilates the arteries.
• Rise of blood flow to the penis tissues and erection: As the arteries widen, it increases the flow of blood inside the penis tissues giving a strong and hard erection easily.

Dapoxetine:

• Stops serotonin from being reused: After getting into action, it stops the SSRI action where serotonin is reused back.
• Getting rid of depression and anxiety: This increases the level of serotonin giving an excited mood free of depression in the mind of the patient that stops early ejaculation issues due to depression or stress.

What should be the dosage of Avanafil and Dapoxetine?

• For mild ED and PE: For mild ED and PE occurring simultaneously the doctors recommend using the Avanafil 20 mg and Dapoxetine 60 mg combined 80 mg dose.
• For severe ED and PE: In case ED is more severe, the doctors can give a different formulation with Avanafil 50 mg and Dapoxetine 30 mg, but the combined dose of 80 mg remains the same.
• Missed dose: Taking the Avanafil and Dapoxetine 80 mg is important before sex for a patient with ED and PE issues or else you may not get the effects of a hard erection or a delayed ejaculation at all.
• Overdose: Excess use of Avanafil or Dapoxetine can easily result in some side effects for the patient. Remember that you are only allowed to use the medicine one time daily at maximum.

Benefits of Taking Avanafil and Dapoxetine 80 mg

• You get a strong erection and have a longer time to have sex and enjoy passion before coming.
• It also has other strengths on offer.
• Gives an erection fast usually within 15 to 20 minutes.
• Using the medicine helps you to get rid of your thoughts on poor sexual performance and avoid stressing out.

What is the major Drug interaction of Avanafil and Dapoxetine?

Drug interactions of Avanafil

• Nitrates: Drugs that contain nitrates or NO donor drugs (used in chest pain treatment) should not be used alongside PDE5 inhibitors, as they may dangerously reduce blood pressure levels.
• Alpha Blockers: These two drugs should not be used simultaneously for blood pressure or prostate problems, as they may result in symptomatic hypotension.
• Guanylate Cyclase Stimulation: This combination is usually discouraged because it causes severe cases of hypotension.

Drug interactions of Dapoxetine

• Monoamine Oxidase Inhibitors (MAOIs): The use of SSRIs together with MAOIs results in severe interactions. Usually, a period must elapse between discontinuation of the one and administration of the other.
• Serotonin Agonists: Concomitant use of other medications known to raise serotonin levels, such as selective antidepressants, lithium, and analgesics, with SSRIs raises the danger of serotonin syndrome.
• CYP3A4 Inhibitors: Antifungal and antiviral drugs might inhibit the metabolic pathways that eliminate SSRIs from the body, resulting in adverse drug reactions.

What are the common side effects of Avanafil and Dapoxetine?

• Headache, Dizziness: Lie down on the bed or sit down for a few minutes until it lasts. If it continues severely talk with a doctor.
• Palpitations: Check out for signs of trembling or sweating and avoid doing work. In case of doubt, contact a doctor.
• Flushing: put water or cold compress on your face, throat, chest, and palms.
• Nausea and vomiting: Avoid taking the medicine in a completely empty stomach or after a heavy meal.

What are the intense side effects of Avanafil and Dapoxetine?

• Chest pain: If you feel tightness in the chest or difficulty, breathing rushes to your doctor immediately.
• Chances of heart attack: checkout for signs of heart throbbing or faster heartbeat, which needs immediate treatment.
• Sudden BP fluctuations: Signs of severe BP fluctuations can cause severe dizziness or even passing out.
• Priapism: A rare side effect where your penis erection stays long after the effect of the medicine is gone. Visit a doctor, as you need immediate treatment.

Precautions and Warnings

• Females to avoid using this medicine: Use of Avanafil and Dapoxetine 80 mg is not safe for females at any age. This is especially true if they are pregnant or breastfeeding a child.
• Age restrictions: The TGA recommends the medicine if your age is more than 18 years with a maximum age limit- 64 years.
• Side effects with alcohol: Alcohol and any other addiction substance can end up causing severe side effects for the patient.
• Avoid taking food items rich in nitrates: Since you are taking a medicine that increases blood flow, doctors do not recommend you take any food items that have high amounts of nitrates in it.
• Liver disorders: Doctors will not recommend in case of severe liver disorders like cirrhosis, fatty liver, liver cancer, or jaundice.
• Kidney disorders: The dilation action of the medicine is not safe in case of issues like kidney failure or severe kidney infection.

When not to use Avanafil and Dapoxetine?

In case of allergic side effects: Avoid taking the medicine if you see signs of allergic side effects like-

• Swelling of the mouth and face
• Difficulty breathing
• Rashes or hives on face, throat

Avoid use with some health issues: The doctors do not recommend using this medicine with:

• High BP
• After a heart surgery
• Severe heart disorder

Storage and disposal

Store the sachet of Avanafil and Dapoxetine 80 mg pills in a region of low temperature and humidity, which should be below 30 degrees Celsius. Avoid direct heat of the sun or extreme wet areas, as the pills can get soggy. Dispose empty sachets and expired medicines without fail.

Where to buy Avanafil and Dapoxetine 80 mg in Australia?

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