SiroBoon

Last Updated on 06/26/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What is Siroboon?

Siroboon is a prescription medicine that is given after a patient has undergone a kidney transplant. Here, the Siroboon pills help to prevent the body from rejecting the newly transplanted kidney.

This medicine helps reduce the attacking activity of immune cells against the new organ. Visit a doctor and are diagnosed completely before the doctor recommends a specific dose and duration.

The doctors will recommend its use only after proper diagnosis. Generally, this medicine is given as a sole remedy in case of transplanted kidney rejection.

Composition and Appearance of Siroboon tablets

• Generic composition: Inside this pill is the generic element of the medicine Sirolimus, which is from the kinase inhibitor group of medicines.
• Appearance: It comes in blister packs with each pack containing 10 pills inside. The medicines are round in shape.

Who makes Siroboon?

Kachhela Medex Private Limited is the manufacturer of the brand name Siroboon.

Pharmacological action and peak effects of Siroboon

1. Peak concentration: As per studies done by the TGA, the action of the drug occurs inside your body after 2 to 3 hours of taking the medicine.
2. Response time: The median response time within patients to show visual changes, as per clinical studies, is found at 2 weeks.
3. Lasting action of each medicine: The action of Siroboon pills in your body is long-lasting, and each pill has a half-life of 57 to 63 hours.

👉 Complete removal: After your course is over, the action of the medicine remains in your body in trace amounts, which disappear after 1 to 2 weeks.

What is the mechanism of action of Siroboon?

How it Works

When Sirolimus gets inside the cell, it attaches to a protein called FKBP-12. This Sirolimus and FKBP-12 then become a working team, a “drug-protein complex”.

Stopping Cell Growth

This team then blocks another protein called mTOR Complex 1 or mTORC1 for short. The mTORC1 protein usually tells cells to grow and divide, like a controller.

Blocking immune proliferation

The drug can stop the system from getting too strong. It does this by blocking the part that makes T-lymphocytes and B-lymphocytes multiply.

These are types of blood cells that help fight off bad things in our bodies. They multiply when they get a signal from things, like Interleukin-2.

Cell Cycle Arrest

The immune cells are stuck in a phase of their life. This phase is called the G1 to S phase. When they are stuck like this, they cannot. Make more cells.

This means they cannot attack an organ or anything else that is not supposed to be attacked by the immune system. The drug puts the cells on hold so they cannot do any harm to the transplanted organ.

What are the Clinical Benefits of Siroboon Tablet?

Physical benefits

• Helps prevent kidney transplant rejection.
• Supports the long-term function of the transplanted kidney.
• Reduces immune system activity to protect the transplanted organ.
• Can be used as part of a combination immunosuppressive therapy.
• Provides long-lasting immunosuppression with once-daily dosing.
• Helps improve long-term transplant outcomes when taken as prescribed.

Note: When taken as prescribed and monitored regularly, Siroboon can help improve long-term kidney transplant outcomes.

Recommended Dosage Guidelines for Siroboon

Initial and maintenance dose

After a kidney transplant, many patients receive an initial loading dose followed by a lower maintenance dose taken once daily.

👉 The exact dose varies from person to person and is adjusted through regular blood tests.

Alternative Conditions

May also be prescribed for certain conditions, such as Lymphangioleiomyomatosis (LAM). The dosage for these conditions is individualized and depends on the patient’s clinical response and blood sirolimus levels.

Pediatric and Lower Weight Dosing

In children and patients weighing less than 40 kg, Siroboon is prescribed according to body surface area (BSA) or body weight. Healthcare providers also monitor blood sirolimus levels regularly to ensure the dose is safe and effective.

Before or after food

You can take it any time of the day, before or after a meal. But once you stick with a routine, make sure to follow the same pattern.

👉 For example, if you are taking the medicine after a meal, keep following that.

Overdose guidelines

Do not increase the dose suddenly or try to use a higher dose without the doctors recommending it first. Overdoses of Siroboon produce some severe side effects for your health.

Missed dose

Never miss taking your medicines and make it a habit occurring quite frequently. This can greatly reduce the impact of the medicine.

SiroBoon (Sirolimus) Tablet Available Strengths

• Siroboon 1 mg
• Siroboon 2 mg
• Siroboon 3 mg
• Siroboon 5 mg

Drug Interactions to Consider with Siroboon

The Siroboon tablet is not suitable for use with –

• Any other immunosuppressants.
• Other medicines to cure kidney infections or severe disorders.
• Certain antivirals, like ritonavir.
• Different types of antibacterial and antifungal medicines, such as ketoconazole.
• Any other pill with the same composition.

👉 Tell the doctors if you are using any such kind of medicine already, and show your existing prescriptions to the doctor.

Precautions & Warnings before starting a dose of Siroboon

• Any other kidney disorder or infection

Patients should also tell their doctor if they have an active infection or existing kidney disease, not just if they’re taking medicines.

• Cancer

Tell the doctors if you have any other kind of cancer affecting critical organs such as the liver or kidneys.

• Liver or kidney disorder

Ensure to tell the doctors if you have issues like high BP, nerve disorders like seizures, or diabetes.

• Alcohol and substance use

Avoid the use of alcohol and other drugs that may only increase the severity of the side effects of Siroboon.

• Before changing the dose

Consult with the doctors before changing your dose, especially if you want to increase the amount of daily use.

👉 Age guidelines: These SiroBoon tablets are only safe for adults above 18 years.

When not to use Sirolimus Tablet?

In case of continuing side effects

Take help from your doctor in case of any continuing side effects. Your doctor will suitably change the dose to reduce or get rid of the side effect.

In case of existing health issues

Always speak with your doctor if you are having stomach pain or urinary issues.

Pregnancy and Breastfeeding

It is not safe to use this medicine during pregnancy or as long as your baby is completely dependent on your breastmilk. Try to avoid getting pregnant when taking the pill.

Allergic issues

There is a small chance that you may be allergic to Siroboon 1 mg.

Storage and Disposal Guidelines

Store Siroboon below 30°C in a cool, dry place away from moisture, heat, and direct sunlight. The sachet of Sirolimus pills in an area of a clean, less hot, and humid place where children would not grasp this pill

👉 For disposal, ensure safety to avoid any kind of contamination.

Where to Buy Siroboon in Australia?

Buy the Siroboon pills online from websites like Australiarxmeds, as they are authentic and licensed by the appropriate authority.