What Do You Need To Know About PDE-5 Inhibitors?
By Ezra Allen, May-07-2024
Dr. Arjun Srivastav Medical Reviewer (Pharm D)PDE-5 inhibitors are a group of medicines mainly used to treat erectile dysfunction (ED). They work by improving blood flow to the penis during sexual stimulation.
Do you know about a class of medicines known as PDE-5 inhibitors and their use? Do you have any idea about male sexual disorders, such as erectile dysfunction?
In this article, we are going to inform you about the PDE-5 inhibitor drug category and how such medicines can help in curing male sexual disorders such as Erectile Dysfunction.
We will also get to know about the suitable dose of such medicines, the possibilities of side effects, and the precautionary measures to prevent the adverse effects. So let’s begin…
Can You Explain What PDE-5 Inhibitors Are And How They Work?
➥ PDE-5 inhibitors are considered medicines in the class of PDE-5 inhibitors. There are several generic medicinal substances, such as Sildenafil, and others. The precise purpose of medications like Cenforce 100 mg is to treat male erectile dysfunction.
➥ All PDE-5 inhibitor pills are prescription medicines. Regardless of the brand and dose you choose, you will need to initially consult with a doctor to know about the safe dosage and the list of safety measures to follow when using such types of medicines.
They block the phosphodiesterase-5 (PDE-5) enzyme
This increases nitric oxide–mediated blood flow
Result: easier and longer-lasting erections (with sexual stimulation)
➥ With the intake of PDE-5 inhibitors, the PDE-5 group of inhibitors would get inhibited, and eventually, it will lead to the vasodilation of the arteries in our body that results in higher movement of blood flow.
This rush of Blood Flow inside the penis tissues results in increasing penis sensitivity and hence helps an impotent patient suffering from ED to even get a hard erection.
➥ With the use of the PDE-5 inhibiting medicines, it is possible to recover from impotence issues,s but not any other form of sexual problems.
Even many patients have a common misconception that the use of the pills can increase their sexual stamina, which is nothing but a myth.
How Do PDE-5 Inhibitors Differ From Other Medicines?
➥ Let us know the different types of medicines that belong to the PDE-5 inhibiting category. There are two subsets of pills here. One is the brand of medicines that have been recommended by the FDA.
➥ But other than that, there is a class of generic medicines where you can find several branded medicinThe the generic branded medicines have similar action to the FDA-recommended medicines. The only difference is in terms of FDA approval, which is not there with the generic pills.
➥ Numerous brands, including Fildena 100 mg, Cenforce, Fildena, Tadacip, Tadalista, Vidalista, Tastylia, and others, are included in these pills.
| Medicines | Tablet | Price | Price/Unit | Buy Now |
|---|---|---|---|---|
| Cenforce | 300 Tablet/s | 306.00 | 1.02 | Buy Now |
| Fildena | 300 Tablet/s | 360.00 | 1.20 | Buy Now |
| Vidalista | 300 Tablet/s | 267.12 | 0.89 | Buy Now |
| Tadalista | 300 Tablet/s | 267.00 | 0.89 | Buy Now |
What Are The Different Generic Medicinal Substances That Belong To This Generic Drug Category?
➥ Now let us know about the generic drug substances that are members of the PDE-5 Inhibiting group of pills. here there are different generic drug substances such as Sildenafil.
Tadalafil, vardenafil, and Avanafil. Such substances are used in the composition of several branded medicines.
Uses
Erectile dysfunction (ED)
Pulmonary arterial hypertension (lower doses, specific brands)
Sometimes used for benign prostatic hyperplasia (tadalafil)
Onset & Duration (approx.)
Sildenafil / Vardenafil: 30–60 min | lasts 4–6 hrs
Tadalafil: 30–45 min | lasts up to 36 hrs
Avanafil: 15–30 min | lasts 6 hrs
Who Should Avoid Them
People taking nitrates (heart medicines)
Severe heart or liver disease
Recent stroke or heart attack
Low blood pressure
How To Choose The Best Drug from the Group Of PDE-5 Inhibitors?
➥ So, how can you pick the PDE-5 Inhibiting medication that’s ideal for you among this large selection? It is safe to argue, then, that anyone with ED who wishes to take these medications ought to receive a doctor’s recommendation.
➥ Remember that not all patients are capable of adjusting to the effects of any one generic substancsuch as Sildenafil or Tadalafil.
It is for the doctors to figure out which one of these generic substances will suit the patient best, depending on the current health condition of the patient and any existing allergic tendencies. You must thus visit the doctors for advice onth dose.
You’ll Feel The Sexual Stimulant Every Time You Take a Dose
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What Is The Dose Of PDE-5 Inhibitors?
➥ Each dose of PDE-5 inhibitors will vary depending on the generic drug substance. For example, Sildenafil comes in normal doses such as 25 mg, 50 mg, 100 mg, 150 mg, and 200 mg. Such doses will have a lasting time of about 4 to 6 hours.
➥ The most recommended doses for Tadalafil include 2.5 mg, 5 mg, 10 mg, 20 mg, and 60 mg. Such doses will have a lasting duration of 24 to 36 hours, which is the longest for any generic substance of the PDE-5 inhibitors category. Avanafil will have doses such as 5 mg, 10 mg, 20 mg, and 40 m,g and usually lasts for about 5 to 7 hours.
What Is The Method Of Intake For PDE-5 Inhibitors?
Generally, the mode of intake will vary for each medicine brand. Generally, the PDE-5 inhibitors come in different medicinal formats. Some of the medicines will need to be swallowed. Other than this, there is a chewable category of medicine that needs to be chewed.
The other most common category of medicine is the sublingual category of medicine that will simply dissolve on its own when you put it in your mouth.
Risk Of Overdose
➥ Yes, whenever you are using any PDE-5 inhibitor pills, there is a risk of overdose. You will need to rigorously follow the dosage instructions of the doctors and take the dose as suggestedbym them.
➥ If you unnecessarily use any higher dose than you are recommended to, the most common consequence will be side effects. For using any such medicine, the safe dose is to use one medicine daily.
What Happens If You Miss A Dose Of PDE-5 Inhibitors?
➥ When you miss taking any PDE-5 inhibitor pill,s the most common issue that you face is the struggle of achieving a strong and hard erection on your own.
Are There Any Risks Of Side Effects With The Use Of PDE-5 Inhibitors?
➥ Yes, all PDE-5 inhibitor pills, such as Fildena 150 mg, will have a chance of causing side effects, especially with an overdose. Some of the most common consequences of an overdose will be a headache, dizziness, nausea, vomiting, diarrhea, stomach cramps, palpitations, nervousness, tremors, flushing, and so on.
➥ If the major side effects occur,ccur you will need to stop taking any further medicines.
What Precautionary Measures Do You Need To Follow With The Use Of PDE-5 Inhibitors?
➥ Use of the Pinhibitor pills is not safe with any form of addictive substance. It isn’t safe for you to drive a car as well after using any such medicine as Vidalista 20 mg.
➥ Generally, the doctors will check your health and if other existing disorders are present. The doctors will generally not recommend using the medicine if you are suffering from critical heart, liver, or kidney disorders.
➥ Similarly, the doctors will not recommend you to use medicines such as blood thinners, or blood pressure inhibitor pills like PDE-5 inhibitors.
Important Tips
Sexual stimulation is required for them to work
Do not take more than prescribed
Avoid excessive alcohol
High-dose use increases side-effect risk
In short
PDE-5 inhibitors are effective, widely used medicines for ED when taken correctly and under medical guidance.
Years of Experience: 12+ Years Education: Master of Sexology - [University of Sydney] MBBS (Bachelor of Medicine, Bachelor of Surgery) - [Torrens University Australia] BSc in Medical Laboratory Technology -…
