Zycel Capsule (Celecoxib)

Last Updated on 05/29/2026 ✔ Medically Reviewed by Dr. Arjun Srivastav

What Is Zycel Capsule?

Zycel Capsule is a prescription medicine containing Celecoxib, a pain-relieving and anti-inflammatory drug. It is commonly used to treat conditions such as osteoarthritis, rheumatoid arthritis, and joint pain.

It is a COX2 inhibitor drug, which belongs to the class of NSAIDs.

With its major ingredient, Celecoxib, this is a prescription drug and is prescribed for managing inflammation and pain. It has a wide range of uses, such as:

• Rheumatoid Arthritis: Reduces swelling of the joints.
• Primary Dysmenorrhea: Giving relief from menstrual cramps.
• Osteoarthritis: Relief from joint pain and tear effect.
• Surgery Pain: Acute pain that results from surgery.
• Spondylitis: Inflammation and pain that affects the spine.

Manufacturer:

Zydus Cadila Pharma

Composition And Appearance:

✓ Active Ingredient:

Celecoxib

✓ Inactive Ingredients:

Lactose Monohydrate, Povidone, Sodium Lauryl Sulphate and Magnesium Stearate.

✓ Appearance:

Hard Gelatin capsule, often featured with a white opaque cap and printed with 100 in black ink on the body.

Onset Of Action:

✓ Peak Plasma Concentration:

2-3 hours.

✓ Pain relief:

Within 30-60 minutes of intake.

✓ Pain relief in chronic conditions:

After 1-2 weeks of regular intake.

✓ Half Life:

11 hours.

How Does Zycel Capsule Work?

Zycel Capsule belongs to a group of medicines called NSAIDs (COX-2 inhibitors). It works by blocking certain chemicals in the body that cause pain, swelling, and inflammation.

✓ Blocks COX2:

Although it is an NSAID drug, it still does not target both COX1 and COX2 enzymes. Rather, it targets only the COX2 enzyme.

✓ Reduce Pain and Inflammation:

COX2 enzyme produces prostaglandins, which are the major cause of pain and inflammation. Inhibiting COX2 helps in giving relief from pain and inflammation.

✓ Spares COX1:

The COX1 enzyme protects your stomach lining. does not inhibit the enzyme. Thus, it makes absorption easier through your digestive system.

Dosage Of Zycel Capsule:

Dosage is different for different types of pain:

✓ Osteoarthritis:

100 mg dose taken twice a day.

✓ Rheumatoid Arthritis:

100 to 200 mg twice a day.

✓ Menstrual Pain:

Start with 400 mg, then go to 200 mg twice a day.

✓ Spondylitis:

Start with 200 mg a day. Then increase it to 400 mg a day as needed.

Benefits Of Zycel Capsule:

✓ Gastrointestinal Tolerance:

Since Zycel does not target the COX1 enzyme, the stomach lining is well maintained. Hence, the common side effects of an NSAID drug, like ulcers or gastrointestinal bleeding, do not result here.

✓ Effective for Surgical Pain:

Surgical pain or Chronic pain causes morning stiffness and joint swelling. By inhibiting the enzyme, COX2, which causes such pains, the symptoms are reduced to a great extent.

✓ Versatile Pain Relief:

The pill can reduce different types of pain, including cramps during menstruation, arthritis and spondylitis pain.

✓ Longer Half-Life:

The drug has a long half-life of 11 hours. Thus, only one to two doses a day are sufficient. This reduces the chances of missing a dose, too.

✓ Safe Bone Marrow:

While dealing with COX1 often leads to a reduction in platelet counts, this does not happen in the case of, as it only deals with COX2. Therefore, bone marrow issues and cardiovascular risks both remain under control.

Drug Interactions:

Interactions With Other Drugs:

✓ Blood thinners:

Taking some anticoagulants can increase the risk of bleeding.

✓ Corticosteroids:

Prednisone or Dexamethasone-like drugs can interact with Zycel to increase the risk of GI perforation.

✓ Antihypertensives:

Drugs like ACE inhibitors and Beta-Blockers reduce blood pressure levels to an absurd level.

✓ Diuretics:

Furosemide-like drugs can reduce the salt-excreting effect in some patients.

✓ Enzyme-controlling medicines:

Fluconazole-like drugs that inhibit the CYP2C9 enzyme increase the concentration of Celecoxib in the body.

On the other hand, certain antidepressants like Paroxetine work with the CYP2D6 enzyme. Since Zycel inhibits the CYP2D6 enzyme, its activity can be hampered.

✓ Antacids:

The absorption rate of Zycel is reduced by the antacids that are based on aluminium and magnesium.

Precautions And Warnings:

✓ Heart Issue:

Thrombotic risk increases with Zycel, and that can lead to heart attacks or stroke, especially in those who have pre-existing heart issues.

✓ Gastro Issues:

Although the risk of ulcers and other gastrointestinal issues is less in the case of Zycel, as it only inhibits COX2, elderly patients can still face the same risk.

✓ Asthma:

If you face asthma triggers after taking any NSAID, then avoid taking Zycel.

✓ Bypass Surgery:

In case you have just gone through a coronary surgery or a bypass, avoid taking the drug.

✓ Renal and Liver issues:

For an impaired kidney, close monitoring with the drug is essential. For liver issues, take the tablet with care unless you have serious liver impairment. For serious liver impairment, avoid taking the capsule.

✓ Pregnancy:

Never take Zycel when you are 20 weeks pregnant. If you are breastfeeding a baby, take the tablet only after consultation.

When Not To Use:

✓ Sulpha Allergy:

Zycel has in it sulphonamide structure, and that can cause absolute contamination if you have a Sulpha Allergy.

✓ Coronary Heart Surgery:

COX2 inhibitors in the post-coronary surgery condition can cause a heart attack or stroke.

✓ Asthma:

If you are asthmatic to any of the NSAIDs, avoid Zycel strictly. It can cause fatal bronchospasm.

✓ 20^th Week Pregnancy:

Never take the pill when you are in the 20^th week and beyond in pregnancy. This can cause fatal heart failure in your baby.

Storage:

Storage:

Store at a place that is neither too hot nor too cold. A room temperature between 25 and 30 degrees Celsius is the ideal temperature for storing the pill. Direct sunlight can make the pills ineffective.

Safety:

Zycel can look like candy to babies. Therefore, make sure that you keep them out of reach of the kids.

Where To Buy Zycel Capsule In Australia?

Always buy Zycel from an authentic store like Australiarxmeds. You will get additional discounts on every purchase from this renowned store in Australia.

You can use a reliable website like australiarxmeds.com for discreet delivery in Australia. You can order Zycel Capsule online from pharmacies. Make sure you only buy from verified and licensed sources to ensure authenticity and safety.