Comparing Armodafinil vs. Modafinil For Better Wakefulness

By Ezra Allen, Dec-10-2025

Written By-Ezra Allen Medical Reviewer, Senior Writer

• Published: 12/10/2025

• Updated: 12/10/2025

✔ Medically Reviewed by

Dr. Arjun Srivastav Medical Reviewer (Pharm D)

🏷️ Key Takeaways:

◾ Waklert 150 Australia (Armodafinil) and Modaheal 200 (Modafinil) work nearly for the same purpose of dealing with day-time sleepiness. However, this medicine can be more effective for some patients as the potential of the same is more than Modafinil.

◾ However, you must rely on your doctor’s prescription, as you need a prescription to avail both the drugs from Australiarxmeds or any genuine medical stores of Australia.

◾ Moreover, depending on your other health issues, your doctor will decide the right medicine for you. Hence, this article is just meant for a comparative study and not to direct you to any particular medicine.

Modafinil – What To Know About It?

Modafinil is an FDA and TGA-approved medicinal component to treat the narcolepsy condition in patients. Modafresh 200, a popular generic medicine with Modafinil, can treat –

Narcolepsy (the irregularity of day-time sleepiness)
Sleep Apnea (issue of breathing trouble during sleeping)
Sleep issue in Shift workers (feeling sleepy during work)

Off-Label Prescribing Modafinil

The main objective of Modafinil is promoting wakefulness in you. This, in turn, lifts up your focus, concentration, and energy level at work and during the day time.

In some cases, doctors prescribe many medicines in assistance to other medicines. They act as associated medicines and are not directly approved by the FDA. However, doctors feel that to treat your main disease, you can face certain syndromes and refers some different medicines. Under such conditions (off-label prescription), Modalert 100 mg Australia (Modafinil) is referred to in the treatment of:

Multiple Solarises, where patients face hazards in the CNS (central nervous system).
Bipolar disorder, where patients experience extreme level of mood swings.
Fatigue syndrome, where you can face fatigue unusually and without any cause for a long time.
Parkinson’s disease, where patients face head shaking.
ADHD condition where patients lose attention to things quite often.

The Usual Dosage Of Modafinil

The dosage of Modafinil can be different for different patients, and all patients must follow the instructions of their doctors. Here is the dosage that patients are usually provided:

For Narcolepsy – 200 mg in the morning (tenure – doctor will decide)
For Sleep Apnea – 200 mg in the morning (daily); tenure should be followed according to the doctor.
For Shift workers – 200 mg 1-2 hours before joining the shift.

Armodafinil – What To Know About It?

Artvigil 150 (Armodafinil) is similar to Modafinil with some minor modifications. This drug is also an FDA and TGA-approved medicine to treat narcolepsy and all the conditions that Modafinil treats, like:

Shift worker sleep apnea, and
Sleep apnea is for Breathing issue.

Off-Label Use Of Armodafinil

Usually recommended for treatment of narcolepsy and wakefulness, doctors also prescribe Armod 150 (armodafinil) as an assisting drug in the treatment of:

Exhaustion in cancer patients.
Parkinson’s disease
Fatigue condition (Chronic)
Multiple Solaris

Usual Dosage Of Armodafinil

Although your doctor will decide the right dosage for you, checking your other health conditions and medical history, here is the usual dosage of armodafinil recommended to patients:

For Narcolepsy Patients – 150-250 mg daily, depending on the condition of the patient.
For Shift workers – 150-250 mg each day according to patient condition.
For Sleep Apnea – 150 mg one hour before starting your shift.

Duration & Metabolism (Science Insight)

Feature	Modafinil	Armodafinil
Half-life	10–12 hours	12–15 hours
Metabolized by	CYP3A4	CYP3A4 (slower)
Breakdown	Faster	Gradual
Stability in blood	Moderate	High

Basic Difference Between Modafinil and Armodafinil

Armodafinil and Modafinil are the same in terms of work, but this medicine has a slight modification than to modafinil. This makes armodafinil more effective at times.

According to the research carried out to find the effect and difference in effect between the two, it has been found that:

In terms of bringing back concentration and focus, both drugs work in the same fashion and provide the same impact.
In terms of working on big projects, too, they work in the same style and yield the same effect on the patients.
Even in terms of showing side effects and drug interactions, both work in the same style and show the same adversities (without any difference in intensity of adversity, too).

However, the study showed that the longevity of both drugs is not the same. While Modawake 200 Mg (Modafinil) works for 12 hours or so, while armodafinil remains in the blood, actively present even after 15 hours of intaking the pill.

Another study on shift workers showed that what Modafinil does with its 200mg dosage, the same is done by Armodafinil with its 150mg dosage.

The Underlying Difference

Analysing both the drugs, it can be hence stated that although modafinil and armodafinil work in the same style and effectivity, there is a difference in longevity between the two. While Modafinil treats all the irregularities that Armodafinil treats, Armodafinil can act for a longer duration and therefore is more effective in a few conditions, like:

Shift workers find more aid with Armodafinil.
Patients with pain from cancer treatment need more hours of activeness, and hence, armodafinil acts better for them.
Those who are into some big projects and need sleepless days and nights with full concentration and wakefulness, armodafinil is the most suitable drug for them.

The Concluding Statement

Therefore, Waklert 150 today with your prescription. While buying the drug from an online store, rely on their genuinity and never look for cheaper items, as you can face counterfeit there. Australiarxmeds is the most trusted house to sell generic medicines at a proper price and with the best delivery policies.

FAQs

Are the side effects caused by Modafinil and Armodafinil the same?

Adversities you can face from Modafinil are almost the same as Armodafinil. The common side effects of both can be –
• Headache
• Anxiety
• Insomnia
• Nausea
• Stomach upset.

Does armodafinil have any serious side effects?

Both modafinil and armodafinil can show the same serious side effects, especially when they react with some other drugs. Some of the serious issues, where consulting a doctor is essential, are –
• Skin reactions or allergy.
• Heart pain or issues with irregular heartbeat.
• Aggression or hallucinations.

Does Modafinil have any serious impact on birth control?

While you take armodafinil or modafinil, it is a better idea to rely on other protection methods (e.g., Condoms) than taking contraceptive pills. It has often been reported that contraceptive pills (especially hormonal) react with both modafinil and armodafinil and form an unanticipated pregnancy.

Can I take armodafinil without food?

Yes, you can take both armodafinil and modafinil without food. However, it is also permissible to take them with food.

Which food must be avoided during treatment with Modafinil?

Never take alcohol while you have taken modafinil. The same goes for armodafinil, even. If you have a plan to take any of these drugs, do not consume alcohol, as the combination can worsen some adversities.

Can I take both Modafinil and armodafinil at the same time?

Never do so, as doing so can trigger some serious heart issues in you. Other side effects can also be triggered for the same reason.

Are modafinil and armodafinil are habit making pills?

They do not have any addictive substances in their composition. However, for the efficacy of the drugs, it can form a habit in you if not taken care of at the initial stage.

Ezra Allen (Medical Reviewer, Senior Writer)

Years of Experience: 12+ Years Education: Master of Sexology - [University of Sydney] MBBS (Bachelor of Medicine, Bachelor of Surgery) - [Torrens University Australia] BSc in Medical Laboratory Technology -…

Read full bio